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anti-Human Cyclin D1 Anticorps:
anti-Mouse (Murine) Cyclin D1 Anticorps:
anti-Rat (Rattus) Cyclin D1 Anticorps:
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Human Polyclonal Cyclin D1 Primary Antibody pour WB - ABIN3044355
Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice. dans Immunology letters 2013
Show all 23 Pubmed References
Human Monoclonal Cyclin D1 Primary Antibody pour ICC, IHC (fro) - ABIN3043639
Ren, Huang, Xu, Yang, Yang, Hu: Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells. dans Anti-cancer drugs 2015
Show all 23 Pubmed References
Human Monoclonal Cyclin D1 Primary Antibody pour IHC (p) - ABIN1687223
Kunder, Calzada-Wack, Hölzlwimmer, Müller, Kloss, Howat, Schmidt, Höfler, Warren, Quintanilla-Martinez et al.: A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: analysis of mouse specific and human antibodies cross-reactive ... dans Toxicologic pathology 2007
Show all 172 Pubmed References
Human Monoclonal Cyclin D1 Primary Antibody pour IHC (p), WB - ABIN1686967
Tsai, Morais, Alshalalfa, Tan, Haddad, Hicks, Gupta, Epstein, Netto, Isaacs, Luo, Mehra, Vessella, Karnes, Schaeffer, Davicioni, De Marzo, Lotan: Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2015
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Human Polyclonal Cyclin D1 Primary Antibody pour WB - ABIN5518654
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. dans International journal of clinical and experimental pathology 2013
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Goat Polyclonal Cyclin D1 Primary Antibody pour FACS, IF (cc) - ABIN671016
Li, Yu, Liu, Zhu, He, Peng, Hua: miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. dans Cell proliferation 2013
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Human Polyclonal Cyclin D1 Primary Antibody pour WB - ABIN1881175
Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. dans Cancer cell 2010
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Human Monoclonal Cyclin D1 Primary Antibody pour FACS, IP - ABIN967430
Bates, Rowan, Vousden: Characterisation of human cyclin G1 and G2: DNA damage inducible genes. dans Oncogene 1996
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Human Monoclonal Cyclin D1 Primary Antibody pour IHC (f), IHC (fro) - ABIN967539
Darzynkiewicz, Gong, Juan, Ardelt, Traganos: Cytometry of cyclin proteins. dans Cytometry 1997
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Human Monoclonal Cyclin D1 Primary Antibody pour ELISA, WB - ABIN969007
Parafioriti, del Bianco, Barisani, Armiraglio, Peretti, Albisetti: Increased p21 expression in chondrocytes of achondroplasic children independently from the presence of the G380R FGFR3 mutation. dans Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2009
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Results suggest that the TCF (Montrer HNF4A Anticorps)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (Montrer CCNDBP1 Anticorps) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (Montrer SMC1A Anticorps) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (Montrer MEIS1 Anticorps) regulating cyclin D1 and c-myc (Montrer MYC Anticorps) transcription in the embryonic eye.
This meta-analysis suggests that the CCND1 G870A polymorphism is associated with an increased risk of colorectal cancer, especially that A carriers may be a major risk factor for colorectal cancer.
results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. Treatment with fascaplysin also suppressed CDK4 (Montrer CDK4 Anticorps), cyclin D1, Bcl-2 (Montrer BCL2 Anticorps), and VEGFA (Montrer VEGFA Anticorps) expression at protein levels
Mutation in the CCND1 gene is associated with acute myeloid leukemia (Montrer BCL11A Anticorps).
The first preclinical study evaluates the response to CDK4/6 (Montrer CDK4 Anticorps) inhibition in endometrial malignancies driven by PTEN (Montrer PTEN Anticorps) deficiency, and it reveals an important role of cyclin D-CDK4/6 (Montrer CDK4 Anticorps) activity in their development.
High CCND1 expression is associated with oropharyngeal squamous cell carcinoma.
Describe a regulatory loop miR (Montrer MLXIP Anticorps)-218-CDK6 (Montrer CDK6 Anticorps)/CyclinD1-E2F1 (Montrer E2F1 Anticorps) whose disruption may contribute to cell cycle progression in gastric cancer.
EGF (Montrer EGF Anticorps) induces hair follicle-derived mesenchymal stem cell proliferation through the EGFR (Montrer EGFR Anticorps)/ERK (Montrer EPHB2 Anticorps) and AKT (Montrer AKT1 Anticorps) pathways, but not through STAT-3 (Montrer STAT3 Anticorps). The G1/S transition was stimulated by upregulation of cyclinD1 and inhibition of p16 (Montrer CDKN2A Anticorps) expression.
Case Report: in the absence of the typical CCND1/IGH@ fusion, t(11;12)(q13;p11.2) promotes Mantle cell lymphoma pathogenesis by eliminating miRNA interaction elements within the 3'-UTR (Montrer UTS2R Anticorps) of the CCND1 mRNA transcript consequently resulting in CCND1 overexpression.
The CCND1 genes were found very close to the IGH locus in naive B cells and further away after maturation. In contrast, the CMYC (Montrer MYC Anticorps) alleles became localized closer to an IGH locus at the stage of SHM (Montrer CNTNAP1 Anticorps)/CSR (Montrer MORF4 Anticorps).
Consistently, samples from oral squamous cell carcinoma (OSCC) patients exhibited a noticeably stronger CREPT (Montrer RPRD1B Anticorps) expression than noncancerous samples. In contrast, knocking down of CREPT (Montrer RPRD1B Anticorps) in OSCC cell lines significantly reduced proliferation, colony formation and migration as well as the expression of cyclin D1 and c-Myc (Montrer MYC Anticorps), but promoted apoptosis.
NMB or NMBR (Montrer NMBR Anticorps) silencing inhibited M-CSF (Montrer CSF1R Anticorps)/c-Fms (Montrer CSF1R Anticorps)-mediated downstream signaling pathways like activation of ERK (Montrer EPHB2 Anticorps) and Akt (Montrer AKT1 Anticorps) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (Montrer CTNNB1 Anticorps)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (Montrer PAX5 Anticorps) and cyclin D1 as Zfp521 (Montrer ZNF521 Anticorps) target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 (Montrer ZNF521 Anticorps) gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (Montrer POU5F1 Anticorps), Sox2 (Montrer SOX2 Anticorps), Klf4 (Montrer KLF4 Anticorps), and c-Myc (Montrer MYC Anticorps) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (Montrer PLCG1 Anticorps) controls osteoclast numbers via a CSF-1 (Montrer CSF1 Anticorps)-dependent DAG/beta-catenin (Montrer CTNNB1 Anticorps)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (Montrer MYC Anticorps), Cyc (Montrer CYCS Anticorps)-D1 and TERT (Montrer TERT Anticorps), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (Montrer DND1 Anticorps) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (Montrer IL33 Anticorps).
Novel RNA-binding activity of MYF5 (Montrer MYF5 Anticorps) enhances Ccnd1 mRNA translation during myogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (Montrer CDK2 Anticorps) and CDK4 (Montrer CDK4 Anticorps) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (Montrer MAPK3 Anticorps) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, Cyclin-D1-binding protein 1 homolog
, cyclin Dx
, cyclin-D1-binding protein 1 homolog
, zebrafish homolog of Maid
, cyclin D1
, G1/S-specific cyclin-D1
, B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, PRAD1 oncogene
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)