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Human Cyclin D1 Kit ELISA pour Sandwich ELISA - ABIN414406
Bocci, Fioravanti, La Motta, Orlandi, Canu, Di Desidero, Mugnaini, Sartini, Cosconati, Frati, Antonelli, Berti, Miccoli, Da Settimo, Danesi: Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. dans Biochemical pharmacology 2011
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Results suggest that the TCF (Montrer HNF4A Kits ELISA)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (Montrer CCNDBP1 Kits ELISA) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (Montrer SMC1A Kits ELISA) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (Montrer MEIS1 Kits ELISA) regulating cyclin D1 and c-myc (Montrer MYC Kits ELISA) transcription in the embryonic eye.
CCND1 plays these essential roles likely through involvement in DNA replication to minimize DNA damage.
MiR (Montrer MLXIP Kits ELISA)-374a inactivates the PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) axis by inhibiting CCND1, suppressing of colon cancer progression.
Overexpression of cyclin D1 results in dysregulated CDK (Montrer CDK4 Kits ELISA) activity, rapid cell growth under conditions of restricted mitogenic signaling, bypass of key cellular checkpoints, and ultimately, neoplastic growth. (Review)
a RAGE (Montrer AGER Kits ELISA)-dependent polyP-mediated crosstalk between mTOR (Montrer FRAP1 Kits ELISA) and the GSK-3 (Montrer GSK3b Kits ELISA)/Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling network can modulate important physiological processes in endothelial cells that involve cyclin D1
Results indicate that miR (Montrer MLXIP Kits ELISA)-134 played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic CCND1.
Patients with tumors with high amplification of CCND1 had an increased risk of recurrence. These findings suggest that CCND1 amplification could be useful for predicting recurrence in invasive breast cancer
Data suggest that subcellular localization of cyclin D1 (Ccnd1) is an interesting guideline to measure cancer outcome.
MEK2 (Montrer MAP2K2 Kits ELISA) was essential for the phosphorylation of MKK3 (Montrer MAP2K3 Kits ELISA)/MKK6 (Montrer MAP2K6 Kits ELISA) and p38 MAPK (Montrer MAPK14 Kits ELISA) that directly impacted on cyclin D1 expression.
miR (Montrer MLXIP Kits ELISA)-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2 (Montrer KDM5A Kits ELISA)/NOTCH1 (Montrer NOTCH1 Kits ELISA)/CYCLIN D1 coregulatory network.
Findings indicate cyclin D1 (CCND1) as a target of microRNA miR (Montrer MLXIP Kits ELISA)-1296.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR (Montrer NMBR Kits ELISA) silencing inhibited M-CSF (Montrer CSF1R Kits ELISA)/c-Fms (Montrer CSF1R Kits ELISA)-mediated downstream signaling pathways like activation of ERK (Montrer EPHB2 Kits ELISA) and Akt (Montrer AKT1 Kits ELISA) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (Montrer CTNNB1 Kits ELISA)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (Montrer PAX5 Kits ELISA) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (Montrer POU5F1 Kits ELISA), Sox2 (Montrer SOX2 Kits ELISA), Klf4 (Montrer KLF4 Kits ELISA), and c-Myc (Montrer MYC Kits ELISA) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (Montrer PLCG1 Kits ELISA) controls osteoclast numbers via a CSF-1 (Montrer CSF1 Kits ELISA)-dependent DAG/beta-catenin (Montrer CTNNB1 Kits ELISA)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (Montrer MYC Kits ELISA), Cyc (Montrer CYCS Kits ELISA)-D1 and TERT (Montrer TERT Kits ELISA), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (Montrer DND1 Kits ELISA) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (Montrer IL33 Kits ELISA).
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (Montrer CDK2 Kits ELISA) and CDK4 (Montrer CDK4 Kits ELISA) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (Montrer MAPK3 Kits ELISA) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, Cyclin-D1-binding protein 1 homolog
, cyclin Dx
, cyclin-D1-binding protein 1 homolog
, zebrafish homolog of Maid
, cyclin D1
, G1/S-specific cyclin-D1
, B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, PRAD1 oncogene
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)