Aperçu des produits pour anti-PDK1 (PDK1) Anticorps

Full name:
anti-Pyruvate Dehydrogenase Kinase, Isozyme 1 Anticorps (PDK1)
Chez www.anticorps-enligne.fr sont 16 Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) Anticorps de 5 de différents fournisseurs disponibles. De plus, nous expédions PDK1 Protéines (8) et PDK1 Kits (7) et beaucoup plus de produits pour cette protéine. Un total de 32 PDK1 produits sont actuellement listés.
Synonymes:
B830012B01, D530020C15Rik, si:zfos-979f1.3

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anti-Mouse (Murine) PDK1 Anticorps:

anti-Human PDK1 Anticorps:

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Plus d’anticorps contre PDK1 partenaires d’interaction

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PDK1 (Montrer PDPK1 Anticorps) has broad effects in hematopoiesis and is a critical factor for engraftment of both hematopoietic stem cells and multipotent progenitors upon transplantation to recipient mice.

  2. our results offer significant insight into how PIK3CA (Montrer PIK3CA Anticorps) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (Montrer PDPK1 Anticorps) and TGFb (Montrer TGFB1 Anticorps) signaling in advanced HNSCC patients with PIK3CA (Montrer PIK3CA Anticorps) amplification

  3. PTEN (Montrer PTEN Anticorps) is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (Montrer PDPK1 Anticorps) is required for stabilization of apical junctions during epithelial morphogenesis.

  4. results thus reveal an essential role for the PDK1 (Montrer PDPK1 Anticorps)-Akt (Montrer AKT1 Anticorps) pathway in the regulation of a key step of neuronal migration.

  5. PDK1 (Montrer PDPK1 Anticorps) plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.

  6. Our data suggest that two arms of the glucose metabolism synergistically regulate the differential activation of macrophages. Our findings also highlight the central role of PDK1 (Montrer PDPK1 Anticorps) in this event via controlling glycolysis and glucose oxidation.

  7. PDHK1 is expressed in Th17 cells, but not Th1 (Montrer HAND1 Anticorps) cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs.

  8. The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC (Montrer PDC Anticorps) binding.

  9. Pdk1 (Montrer PDPK1 Anticorps) enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis

Human Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Ribociclib, in combination with GSK2334470 or the PI3Kalpha (Montrer PIK3CA Anticorps) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (Montrer PIK3CA Anticorps)-PDK1 signaling pathway in mediating acquired resistance to CDK4/6 (Montrer CDK4 Anticorps) inhibitors.

  2. dicumarol potently inhibited the kinase activity of PDK1, shifted the glucose metabolism from aerobic glycolysis to oxidative phosphorylation, generated a higher level of reactive oxygen species (ROS (Montrer ROS1 Anticorps)), attenuated the mitochondrial membrane potential (MMP), induced apoptosis, and reduced cell viability in vitro.

  3. our results offer significant insight into how PIK3CA (Montrer PIK3CA Anticorps) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (Montrer PIK3CA Anticorps)/PDK1 and TGFb (Montrer TGFB1 Anticorps) signaling in advanced HNSCC patients with PIK3CA (Montrer PIK3CA Anticorps) amplification

  4. miR (Montrer MLXIP Anticorps)-379 could function as a tumour-suppressing miRNA via targeting PDK1 in osteosarcoma.

  5. These results also suggest that inhibition of HIF-1a (Montrer HIF1A Anticorps) with 2-MeOE2 sensitizes radioresistant melanoma cells 435R to X-ray irradiation through targeting the glycolysis that is regulated by PDK1

  6. PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker.

  7. A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.

  8. Our results demonstrated that down-regulation of SDHB (Montrer SDHB Anticorps) and up-regulation of PDK1 may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in recurrent nasopharyngeal carcinoma patients

  9. n the conditon of miR (Montrer MLXIP Anticorps)- 128b over-expression, we also observed spontaneous inactivation of the Akt (Montrer AKT1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) signalling, implying PDK1 was a potential regulator of this pathway. In conclusion, our study shed some novel light on miR (Montrer MLXIP Anticorps)-128b-PDK1/Akt (Montrer AKT1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) axis onGastric cancer (GC) progression

  10. Dichloroacetate, an Iihibitor of PDK1, can reverse the mitochondrial suppression of renal cell carcinoma (Montrer MOK Anticorps) and decrease HIF transcriptional activity, decreasing tumor growth and angiogenesis.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa.

PDK1 profil antigène

Antigen Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Alternative names and synonyms associated with PDK1

  • pyruvate dehydrogenase kinase, isozyme 1 (PDK1) anticorps
  • pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1) anticorps
  • pyruvate dehydrogenase kinase, isozyme 1 (Pdk1) anticorps
  • pyruvate dehydrogenase kinase, isozyme 1 (pdk1) anticorps
  • B830012B01 anticorps
  • D530020C15Rik anticorps
  • si:zfos-979f1.3 anticorps

Protein level used designations for PDK1

pyruvate dehydrogenase kinase, isoenzyme 1 , pyruvate dehydrogenase kinase, isozyme 1 , pyruvate dehydrogenase [lipoamide] kinase isozyme 1, mitochondrial-like , PDH kinase 1 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial , mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1 , PDK p48 , pyruvate dehydrogenase kinase 1

GENE ID SPECIES
100218846 Taeniopygia guttata
100402844 Callithrix jacchus
100601990 Nomascus leucogenys
228026 Mus musculus
5163 Homo sapiens
116551 Rattus norvegicus
555840 Danio rerio
425972 Gallus gallus
100286871 Sus scrofa
528655 Bos taurus
476828 Canis lupus familiaris
432080 Xenopus laevis
100064091 Equus caballus
100351323 Oryctolagus cuniculus
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