Aperçu des produits pour anti-PDPK1 (PDPK1) Anticorps

Full name:
anti-3-phosphoinositide Dependent Protein Kinase-1 Anticorps (PDPK1)
Chez www.anticorps-enligne.fr sont 467 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps de 31 de différents fournisseurs disponibles. De plus, nous expédions PDPK1 Protéines (28) et PDPK1 Kits (25) et beaucoup plus de produits pour cette protéine. Un total de 551 PDPK1 produits sont actuellement listés.
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787

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anti-PDPK1 Anticorps mieux référencés

  1. Human Polyclonal PDPK1 Primary Antibody pour EIA - ABIN358390 : Nilsen, Slagsvold, Skjerpen, Brech, Stenmark, Olsnes: Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. dans The Journal of biological chemistry 2004 (PubMed)
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  2. Human Polyclonal PDPK1 Primary Antibody pour IF, IHC (p) - ABIN196616 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. dans Molecular and cellular biology 2005 (PubMed)
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  3. Human Polyclonal PDPK1 Primary Antibody pour ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. dans The Biochemical journal 2014 (PubMed)
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  4. Human Polyclonal PDPK1 Primary Antibody pour EIA, WB - ABIN359095 : Frödin, Antal, Dümmler, Jensen, Deak, Gammeltoft, Biondi: A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. dans The EMBO journal 2002 (PubMed)
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  5. Human Polyclonal PDPK1 Primary Antibody pour ELISA, WB - ABIN185505 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. dans Science (New York, N.Y.) 2005 (PubMed)

  6. Human Polyclonal PDPK1 Primary Antibody pour IHC, ELISA - ABIN1532025 : Stephens, Anderson, Stokoe, Erdjument-Bromage, Painter, Holmes, Gaffney, Reese, McCormick, Tempst, Coadwell, Hawkins: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. dans Science (New York, N.Y.) 1998 (PubMed)

  7. Cow (Bovine) Polyclonal PDPK1 Primary Antibody pour WB - ABIN2779320 : Lin, Hsieh, Song, Lin: Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. dans British journal of cancer 2005 (PubMed)

  8. Human Polyclonal PDPK1 Primary Antibody pour IF (p), IHC (p) - ABIN744668 : Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. dans Epilepsy research 2015 (PubMed)

  9. Cow (Bovine) Polyclonal PDPK1 Primary Antibody pour WB - ABIN2777432 : Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: Amlodipine inhibits cell proliferation via PKD1-related pathway. dans Biochemical and biophysical research communications 2008 (PubMed)

Plus d’anticorps contre PDPK1 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (Montrer CDK7 Anticorps) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (Montrer IL1B Anticorps)pared to (Montrer IL6 Anticorps)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (Montrer RPS6KA3 Anticorps)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (Montrer TNF Anticorps)gress of RA.

  3. PDK1 is required for Ca(2 (Montrer CA2 Anticorps)+)-dependent platelet activation on stimulation of collagen receptor (Montrer ITGA2 Anticorps) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (Montrer INS Anticorps)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (Montrer IRS1 Anticorps)/PDPK1/AKT (Montrer AKT1 Anticorps) insulin (Montrer INS Anticorps) pathway by interacting with its GAP ASAP2 (Montrer ASAP2 Anticorps) and activating PDPK1. This research may provide new insights into GTPase (Montrer RACGAP1 Anticorps)-mediated insulin (Montrer INS Anticorps) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (Montrer INS Anticorps) sensitizati

  5. Only when suboptimal doses of Akt (Montrer AKT1 Anticorps)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (Montrer NOTCH1 Anticorps) inhibition was seen. We conclude that the Akt (Montrer AKT1 Anticorps) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (Montrer AKT1 Anticorps) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (Montrer NFKB1 Anticorps).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (Montrer BCR Anticorps)-induced signal transduction to Foxo (Montrer FOXO3 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (Montrer PDK1 Anticorps) could promote cell invasion and secretion of IL-1beta (Montrer IL1B Anticorps) and IL-6 (Montrer IL6 Anticorps) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (Montrer RPS6KA3 Anticorps) reduced the PDK1 (Montrer PDK1 Anticorps)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (Montrer TNF Anticorps), PDK1 (Montrer PDK1 Anticorps) could phosphorylate RSK2 (Montrer RPS6KA3 Anticorps) and activated RSK2 (Montrer RPS6KA3 Anticorps), then promoting the activation of NF-kappaB (Montrer NFKB1 Anticorps).

  2. In cancer cells resistant to PI3Kalpha (Montrer PIK3CA Anticorps) inhibition, PDK1 (Montrer PDK1 Anticorps) blockade restores sensitivity to these therapies. SGK1 (Montrer SGK1 Anticorps), which is activated by PDK1 (Montrer PDK1 Anticorps), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (Montrer TSC2 Anticorps).

  3. Results suggest that Ser (Montrer SIGLEC1 Anticorps)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (Montrer PDK1 Anticorps)-PKCtheta (Montrer PRKCQ Anticorps);-mediated T cell activation.

  4. Elevated expression of PDK1 (Montrer PDK1 Anticorps) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (Montrer MLXIP Anticorps)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (Montrer PDK1 Anticorps).

  6. miR (Montrer MLXIP Anticorps)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (Montrer PDK1 Anticorps) expression.

  7. Decreased PDK1 (Montrer PDK1 Anticorps) level is closely associated with reduced Akt (Montrer AKT1 Anticorps)/cyclin D1 (Montrer CCND1 Anticorps) activity.

  8. MiR (Montrer MLXIP Anticorps)-138 regulation of PI3K (Montrer PIK3CA Anticorps) signaling in ASMCs by altering the expression of PDK1 (Montrer PDK1 Anticorps).

  9. Dephosphorylation of PDK-1 (Montrer PDK1 Anticorps) and the resulting changes to Akt (Montrer AKT1 Anticorps) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (Montrer CLDN18 Anticorps) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (Montrer CDK7 Anticorps)-1 and proto-oncogene (Montrer RAB1A Anticorps) protein c (Montrer PROC Anticorps)-akt (Akt (Montrer AKT1 Anticorps)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (Montrer MYLIP Anticorps)-375 directly targeted PDK1 (Montrer PDK1 Anticorps) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (Montrer PIK3C3 Anticorps) (PI3K)

PDPK1 profil antigène

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) anticorps
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) anticorps
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) anticorps
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) anticorps
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) anticorps
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) anticorps
  • Phosphoinositide-dependent kinase 1 (Pdk1) anticorps
  • Protein PDK-1 (pdk-1) anticorps
  • 1210 anticorps
  • BG02759 anticorps
  • CG1201 anticorps
  • CG1210 anticorps
  • Dmel\\CG1210 anticorps
  • dPDK-1 anticorps
  • dPDK1 anticorps
  • dSTPK61 anticorps
  • MGC82080 anticorps
  • PDK anticorps
  • PDK-1 anticorps
  • Pdk1 anticorps
  • PDK1/Pk61C anticorps
  • pdpk1 anticorps
  • PDPK2 anticorps
  • pk61c anticorps
  • Pk61C/PDK1 anticorps
  • PRO0461 anticorps
  • zgc:153787 anticorps

Protein level used designations for PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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