anti-Humain PDPK1 anticorps pour Intracellular Staining

Recommended PDPK1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • zgc:153787
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase-1a
  • 3-phosphoinositide-dependent protein kinase 1
  • Phosphoinositide-dependent kinase 1
  • Protein PDK-1
  • PDPK1
  • pdpk1
  • Pdpk1
  • pdpk1a
  • Pdk1
  • pdk-1
Épitope
pSer241
59
35
32
27
27
26
18
17
15
15
15
15
8
7
6
6
6
5
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
465
220
220
19
13
12
11
11
6
5
4
3
2
1
1
1
1
1
1
1
Hôte
Souris
384
72
16
Clonalité
Monoclonal
Conjugué
Cet anticorp PDPK1 est conjugé à/à la PE
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
5
5
5
4
4
3
3
3
2
2
1
1
1
1
1
1
Application
Intracellular Staining (ICS)
314
158
102
91
67
66
40
31
22
10
7
5
2
2
1
Options
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N° du produit ABIN1177136
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN1177137 ICS Alexa Fluor 647 Mouse IgG1, kappa pSer241 Connectez-vous pour afficher J66-653-44-17 1
1 ABIN1177138 ICS Alexa Fluor 488 Mouse IgG1, kappa pSer241 Connectez-vous pour afficher J66-653-44-17 1

General

Antigène 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps
Épitope pSer241
(59), (35), (32), (27), (27), (26), (18), (17), (15), (15), (15), (15), (8), (7), (6), (6), (6), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(465), (220), (220), (19), (13), (12), (11), (11), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Hôte Souris
(384), (72), (16)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp PDPK1 est conjugé à/à la PE
(19), (17), (16), (11), (11), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (5), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Application Intracellular Staining (ICS)
(314), (158), (102), (91), (67), (66), (40), (31), (22), (10), (7), (5), (2), (2), (1)
Pubmed 1 référence disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-PDPK1 anticorps

Détail du antigène PDPK1 Information d'application Stockage References for anti-PDPK1 antibody (ABIN1177136) Images
Marque BD Phosflow™
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogène Phosphorylated Human PDPK1 Peptide
Clone J66-653-44-17
Isotype IgG1, kappa

Détail du antigène PDPK1

Détail du produit anti-PDPK1 anticorps Information d'application Stockage References for anti-PDPK1 antibody (ABIN1177136) Images Haut de la page
Antigène
Autre désignation PDPK1 (PDPK1 Antibody Extrait)
Sujet The serine/threonine kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDPK1, also known as PDK1) contributes to the activation of many important kinases in the insulin and IGF-1 signaling pathways. It acts downstream of phosphatidylinositol 3-kinase (PI3-kinase) to phosphorylate residues in the activation loops of many cellular kinases, including protein kinase B (PKB/Akt), PKC isoforms, p70 S6 kinase, and PDPK1 itself. The autophosphorylation of PDPK1 at serine 241 (S241) has recently been suggested to play a role in the regulation of PDPK1. It has been proposed that PDPK1 activity plays a key role in the regulation of various cellular events such as cell proliferation, differentiation, and apoptosis. The J666-653.44.17 monoclonal antibody recognizes the phosphorylated S241 in the activation loop of human PDPK1. The orthologous phosphorylation site in mouse and rat PDPK1 is S244.
Synonyms: PDK1 (pS241), PKB Kinase (pS241)
Domaine de recherche Kinases/Phosphatases
Pathways Signalisation PI3K-Akt, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals

Information d'application

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Stockage References for anti-PDPK1 antibody (ABIN1177136) Images Haut de la page
Volume d'échantillon 20 μL
Restrictions For Research Use only

Stockage

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Information d'application References for anti-PDPK1 antibody (ABIN1177136) Images Haut de la page
Format Liquid
Buffer Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References for anti-PDPK1 antibody (ABIN1177136)

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Information d'application Stockage Images Haut de la page
Produit citée dans:

Komander, Kular, Deak, Alessi, van Aalten: "Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding." dans: The Journal of biological chemistry, Vol. 280, Issue 19, pp. 18797-802, 2005