anti-Souris PDPK1 anticorps pour Immunofluorescence (Paraffin-embedded Sections)

Recommended PDPK1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • zgc:153787
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase-1a
  • 3-phosphoinositide-dependent protein kinase 1
  • Phosphoinositide-dependent kinase 1
  • Protein PDK-1
  • PDPK1
  • pdpk1
  • Pdpk1
  • pdpk1a
  • Pdk1
  • pdk-1
Épitope
pSer241
59
35
32
27
27
26
18
17
15
15
15
15
8
7
6
6
6
5
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
465
220
220
19
13
12
11
11
6
5
4
3
2
1
1
1
1
1
1
1
Hôte
Lapin
383
73
16
Clonalité
Polyclonal
Conjugué
Cet anticorp PDPK1 est non-conjugé
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
6
5
5
4
4
3
3
3
2
2
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
313
158
102
90
66
66
40
31
22
10
7
5
3
2
1
Options
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N° du produit ABIN744668
$ 329.45
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN682948 IF (p) IHC (p) WB Rabbit IgG pTyr373, pTyr376 Connectez-vous pour afficher Polyclonal
1 ABIN711116 IF (p) IHC (p) WB Rabbit IgG pTyr9 Connectez-vous pour afficher Polyclonal
1 ABIN744671 IF (p) Cy3 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN744672 IF (p) Cy5 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN744673 IF (p) Cy5.5 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN744674 IF (p) Cy7 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN744675 IF (p) FITC Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN875009 IF (p) Alexa Fluor 555 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN875011 IF (p) Alexa Fluor 488 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN875012 IF (p) Alexa Fluor 647 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN875013 IF (p) Alexa Fluor 350 Rabbit IgG pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN2814978 IF (p) Alexa Fluor 594 Rabbit IgG AA 220-260, pSer241 Connectez-vous pour afficher Polyclonal
1 ABIN711135 IF (p) Cy5 Rabbit IgG pSer396 Connectez-vous pour afficher Polyclonal
1 ABIN711136 IF (p) Cy5.5 Rabbit IgG pSer396 Connectez-vous pour afficher Polyclonal
1 ABIN711137 IF (p) Cy7 Rabbit IgG pSer396 Connectez-vous pour afficher Polyclonal
1 ABIN711138 IF (p) FITC Rabbit IgG pSer396 Connectez-vous pour afficher Polyclonal
1 ABIN711149 IF (p) Cy3 Rabbit IgG pSer410 Connectez-vous pour afficher Polyclonal
1 ABIN711150 IF (p) Cy5 Rabbit IgG pSer410 Connectez-vous pour afficher Polyclonal
1 ABIN711151 IF (p) Cy5.5 Rabbit IgG pSer410 Connectez-vous pour afficher Polyclonal
1 ABIN711152 IF (p) Cy7 Rabbit IgG pSer410 Connectez-vous pour afficher Polyclonal

General

Antigène 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps
Épitope pSer241
(59), (35), (32), (27), (27), (26), (18), (17), (15), (15), (15), (15), (8), (7), (6), (6), (6), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(465), (220), (220), (19), (13), (12), (11), (11), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Hôte Lapin
(383), (73), (16)
Clonalité
Polyclonal
Conjugué Cet anticorp PDPK1 est non-conjugé
(19), (17), (16), (11), (11), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(313), (158), (102), (90), (66), (66), (40), (31), (22), (10), (7), (5), (3), (2), (1)
Pubmed 1 référence disponible
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Détail du produit anti-PDPK1 anticorps

Détail du antigène PDPK1 Information d'application Stockage References for anti-PDPK1 antibody (ABIN744668) Images
Specificité This phosphorylation site is homologous to Ser244 in Mouse and Rat.
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241
Isotype IgG

Détail du antigène PDPK1

Détail du produit anti-PDPK1 anticorps Information d'application Stockage References for anti-PDPK1 antibody (ABIN744668) Images Haut de la page
Antigène
Autre désignation Pdk1 (PDPK1 Antibody Extrait)
Sujet

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses.

Subcellular location: Cytoplasm, Membrane bound

Synonyms: PDK1, PDPK2, PDPK2P, PRO0461, 3-phosphoinositide-dependent protein kinase 1, hPDK1, PDPK1

ID gène 5170
UniProt O15530
Domaine de recherche Signaling, Cytoskeleton, Microfilaments, Kinases/Phosphatases
Pathways Signalisation PI3K-Akt, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals

Information d'application

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Stockage References for anti-PDPK1 antibody (ABIN744668) Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Information d'application References for anti-PDPK1 antibody (ABIN744668) Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

References for anti-PDPK1 antibody (ABIN744668)

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Information d'application Stockage Images Haut de la page
Produit citée dans:

Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: "Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy." dans: Epilepsy research, Vol. 112, pp. 137-49, 2015

Images

Détail du produit anti-PDPK1 anticorps Détail du antigène PDPK1 Information d'application Stockage References for anti-PDPK1 antibody (ABIN744668) Haut de la page
Supplier Images
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Mouse bone lysates probed with Rabbit Anti-PDK1(ser241) Polyclonal Antibody, Unconjug...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) paraformaldehyde-fixed, paraffin embedded human live carcinoma tissue, Antigen retrie...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) paraformaldehyde-fixed, paraffin embedded human breast carcinoma tissue, Antigen retr...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Paraformaldehyde-fixed, paraffin embedded rat kidney tissue, Antigen retrieval by boi...
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Lane 1: Mouse brain lysates, Lane 2: Mouse heart lysates probed with PDK1(Ser241) Pol...