Aperçu des produits pour anti-PIK3CA (PIK3CA) Anticorps

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Anticorps (PIK3CA)
Chez www.anticorps-enligne.fr sont 163 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Anticorps de 28 de différents fournisseurs disponibles. De plus, nous expédions PIK3CA Kits (10) et PIK3CA Protéines (4) et beaucoup plus de produits pour cette protéine. Un total de 186 PIK3CA produits sont actuellement listés.
Synonymes:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
afficher tous les anticorps Gène GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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anti-PIK3CA Anticorps mieux référencés

  1. Human Monoclonal PIK3CA Primary Antibody pour IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. dans The Journal of biological chemistry 1999 (PubMed)
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  2. Chicken Monoclonal PIK3CA Primary Antibody pour BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. dans Cell 1991 (PubMed)
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  3. Human Polyclonal PIK3CA Primary Antibody pour EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. dans Oncogene 2008 (PubMed)
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  4. Human Monoclonal PIK3CA Primary Antibody pour ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. dans Cancer research 2009 (PubMed)
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  5. Human Polyclonal PIK3CA Primary Antibody pour IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. dans Genes & development 2002 (PubMed)
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  6. Human Polyclonal PIK3CA Primary Antibody pour FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. dans Nature immunology 2009 (PubMed)
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  7. Human Polyclonal PIK3CA Primary Antibody pour IHC, ELISA - ABIN334459 : López-Knowles, Hernández, Malats, Kogevinas, Lloreta, Carrato, Tardón, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. dans Cancer research 2006 (PubMed)
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  8. Human Monoclonal PIK3CA Primary Antibody pour EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. dans Oncogene 2004 (PubMed)
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  9. Human Polyclonal PIK3CA Primary Antibody pour IF (p), IHC (p) - ABIN677198 : Paul-Samojedny, Suchanek, Borkowska, Pude?ko, Owczarek, Kowalczyk, Machnik, Fila-Dani?ow, Kowalski: Knockdown of AKT3 (PKB?) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells. dans BioMed research international 2014 (PubMed)

Plus d’anticorps contre PIK3CA partenaires d’interaction

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Studies indicate that the Pten (Montrer PTEN Anticorps)+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten (Montrer PTEN Anticorps) is a key regulatory player in the PI3K/PTEN (Montrer PTEN Anticorps)/AKT (Montrer AKT1 Anticorps) pathway.

  2. our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (Montrer PDPK1 Anticorps) and TGFb (Montrer TGFB1 Anticorps) signaling in advanced HNSCC patients with PIK3CA amplification

  3. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (Montrer HSP90 Anticorps) and the PI3K/AKT (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) pathway in prostate cancer.

  4. Data indicate that chlorogenic acid (CGA (Montrer CGA Anticorps)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (Montrer AKT1 Anticorps)-mediated activation of Nrf2 (Montrer NFE2L2 Anticorps)/HO-1 (Montrer HMOX1 Anticorps) pathway, which may be an effective drug in treatment of osteoporosis.

  5. Data show that macrophage M2 polarization was mediated through PTEN (Montrer PTEN Anticorps)/PI3k/AKT (Montrer AKT1 Anticorps) pathway activation.

  6. Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.

  7. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (Montrer AGGF1 Anticorps) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)

  8. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (Montrer PRKAA2 Anticorps)

  9. The mRNA levels of leptin (Montrer LEP Anticorps) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  10. Results suggest a role of ST6GalNAc I (Montrer ST6GALNAC1 Anticorps) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (Montrer AKT1 Anticorps)/NF-kappa B (Montrer NFKB1 Anticorps) signaling, and ST6GalNAc I (Montrer ST6GALNAC1 Anticorps) might be a marker for the prognosis and therapy of hepatocarcinoma.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. High PI3K expression is associated with melanoma.

  2. Data indicate that PI3K pathway mutation predicts longer time to local progression after radioembolization of colorectal liver metastases.

  3. Oncogenic beta-catenin (Montrer CTNNB1 Anticorps) and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.

  4. Results indicate that p110alpha primarily mediates PI3K/AKT (Montrer AKT1 Anticorps) signaling in HER2 (Montrer ERBB2 Anticorps)+ PTEN (Montrer PTEN Anticorps) deficient breast tumors whereas p110beta conditionally mediates HER2 (Montrer ERBB2 Anticorps)/PI3K signaling in the absence of p110alpha.

  5. Cytokines IL-2 (Montrer IL2 Anticorps)/7/9 stimulation activates PI3K/Akt (Montrer AKT1 Anticorps) pathways downstream of Ras in RasGRP1 (Montrer RASGRP1 Anticorps) T-cell acute lymphoblastic leukemia (T-ALL).

  6. This study revealed that (1) PIK3CA hotspot mutations occurred with low frequency in gastric cancer; (2) PIK3CA hotspot mutations were not directly associated with PI3K pathway activation; and (3) p-AKT (Montrer AKT1 Anticorps) (+) may be a biomarker for better outcomes for gastric cancer patients undergoing gastrectomy regardless of the PIK3CA mutation status.

  7. Findings indicate that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1 (Montrer PDLIM7 Anticorps)), PI3K/AKT (Montrer AKT1 Anticorps), miR (Montrer MLXIP Anticorps)-21 and PTEN (Montrer PTEN Anticorps) constitute a positive feedback loop and have a key role in LMP1 (Montrer PDLIM7 Anticorps)-induced cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC (Montrer NPC1 Anticorps)).

  8. Data suggest that Lys-776 (in the P-loop of PIK3CA) is critical for autophosphorylation in PIK3CA/PIK3R1 heterodimer; both His-936 and His-917 (in the activation and catalytic loops of PIK3CA) are important catalytically, but appear to have different functions; bisubstrate kinetic analysis of PIK3CA/PIK3R1 heterodimer indicates an ordered sequential mechanism.

  9. PIK3CA mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.

  10. Tetraarsenic hexoxide (As4O6) induced G2/M arrest, apoptosis and autophagic cell death through PI3K/Akt (Montrer AKT1 Anticorps) and p38 MAPK (Montrer MAPK14 Anticorps) pathways alteration in SW620 colon cancer cells.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (Montrer ITSN1 Anticorps) unfolding.

  2. PI3K has a role in activation of 5'-AMP (Montrer TMPRSS5 Anticorps)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (Montrer PIK3C2A Anticorps) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA profil antigène

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) anticorps
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) anticorps
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) anticorps
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) anticorps
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) anticorps
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) anticorps
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) anticorps
  • 6330412C24Rik anticorps
  • C-P3K anticorps
  • caPI3K anticorps
  • CLOVE anticorps
  • CWS5 anticorps
  • MCAP anticorps
  • MCM anticorps
  • MCMTC anticorps
  • p110 anticorps
  • p110-alpha anticorps
  • p110alpha anticorps
  • pi3-k anticorps
  • PI3-kinase anticorps
  • PI3K anticorps
  • PI3K-alpha anticorps

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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