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anti-Mouse (Murine) PPP2R4 Anticorps:
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Human Monoclonal PPP2R4 Primary Antibody pour ICC, FACS - ABIN969557
Yoon, Jun, Park, Jun Yoo, Moon, Soon Baik, Kim, Kim, Kim, Koh, Taek Lee, You: Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. dans Stem cells (Dayton, Ohio) 2010
Show all 2 Pubmed References
Human Monoclonal PPP2R4 Primary Antibody pour IP, WB - ABIN1042656
Fellner, Lackner, Hombauer, Piribauer, Mudrak, Zaragoza, Juno, Ogris: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. dans Genes & development 2003
Human Polyclonal PPP2R4 Primary Antibody pour ELISA, WB - ABIN4347103
Gushiken, Patel, Liu, Pradhan, Bergeron, Peng, Vijayan: Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. dans The Journal of biological chemistry 2008
data indicate that PTPalpha (Montrer PTPRA Anticorps) and FAK (Montrer PTK2 Anticorps), which are enriched in FAs (Montrer FAS Anticorps), interact with IP3R1 (Montrer ITPR1 Anticorps) at adjacent ER sites to spatially sequester IL-1 (Montrer IL1A Anticorps)-induced Ca(2 (Montrer CA2 Anticorps)+) signalling
oocyte-specific deletion of Ppp2r1a (Montrer PPP2R1A Anticorps) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (Montrer PPP2R2B Anticorps) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (Montrer PLK4 Anticorps) autophosphorylation, thus stabilizing Plk4 (Montrer PLK4 Anticorps) and promoting centriole duplication
PP2A (Montrer PPP2R2B Anticorps)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (Montrer TFAP2A Anticorps), CREB (Montrer CREB1 Anticorps), ETS-1 (Montrer ETS1 Anticorps), and SP-1 (Montrer SP1 Anticorps)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (Montrer CASP3 Anticorps)-dependent apoptosis
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (Montrer RPS3 Anticorps) by both activating PKCdelta (Montrer PKCd Anticorps) and blocking the PP2A (Montrer PPP2R2B Anticorps) interaction with rpS3 (Montrer RPS3 Anticorps)
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (Montrer PPP2R2B Anticorps) prevents the inhibitory function of CTLA-4 (Montrer CTLA4 Anticorps), before TCR-CTLA-4 (Montrer CTLA4 Anticorps) coligation.
The present results indicate that rs959627 predicts PPP2R2 B mRNA prefrontal expression in two independent post-mortem datasets as well as lateral prefrontal activity during working memory in healthy subjects and suggest that genetic modulation of signal transduction mediated by PP2A affects complex biological phenotypes of relevance for cognitive behavior.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (Montrer IFNA Anticorps) signaling via increased expression of SOCS3 (Montrer SOCS3 Anticorps) and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps)/c-Jun (Montrer JUN Anticorps)).
The aim of this review is to shed light on the role of four different phosphatases (PTEN (Montrer PTEN Anticorps), PP2A, CDC25 (Montrer RASGRF1 Anticorps) and DUSP1 (Montrer DUSP1 Anticorps)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Oncoprotein CIP2A (Montrer KIAA1524 Anticorps) is stabilized via interaction with tumor suppressor PP2A/B56
Such effect by miR (Montrer MLXIP Anticorps)-429 was again abolished with AMPKalpha1 (Montrer PRKAA1 Anticorps) silence or mutation. Together, we propose that PP2A-c silence by miR (Montrer MLXIP Anticorps)-429 activates AMPK (Montrer PRKAA1 Anticorps) and protects osteoblastic cells from Dex.
PTPalpha (Montrer PTPRA Anticorps) is identified as a novel substrate of N-Acetylglucosaminyltransferase V (GnT-V (Montrer MGAT5 Anticorps)) and could be a factor regulating promotion of migration in breast cancer cells
This article reviews the involvement of PP2A in the regulation of three cell signaling pathways: wnt (Montrer WNT2 Anticorps), mTOR (Montrer FRAP1 Anticorps) and MAP kinase (Montrer MAPK1 Anticorps), as well as the G1-->S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases. [review]
PP2A-B55 (Montrer MINK1 Anticorps) substrates were identified and assigned their temporal order in mitotic exit.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A