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Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer.
data indicate that PTPalpha (Montrer PTPRA Kits ELISA) and FAK (Montrer PTK2 Kits ELISA), which are enriched in FAs (Montrer FAS Kits ELISA), interact with IP3R1 (Montrer ITPR1 Kits ELISA) at adjacent ER sites to spatially sequester IL-1 (Montrer IL1A Kits ELISA)-induced Ca(2 (Montrer CA2 Kits ELISA)+) signalling
oocyte-specific deletion of Ppp2r1a (Montrer PPP2R1A Kits ELISA) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (Protein Phosphatase 2A(Twins)) counteracts Plk4 (Montrer PLK4 Kits ELISA) autophosphorylation, thus stabilizing Plk4 (Montrer PLK4 Kits ELISA) and promoting centriole duplication
PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (Montrer TFAP2A Kits ELISA), CREB (Montrer CREB1 Kits ELISA), ETS-1 (Montrer ETS1 Kits ELISA), and SP-1 (Montrer SP1 Kits ELISA)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A prevents the inhibitory function of CTLA-4 (Montrer CTLA4 Kits ELISA), before TCR-CTLA-4 (Montrer CTLA4 Kits ELISA) coligation.
PP-2A regulation of paxillin (Montrer PXN Kits ELISA) phosphorylation may have a role in controlling tumor cell adherence and motility.
Isoliensinine suppresses NF-kappaB (Montrer NFKB1 Kits ELISA) in hepatocellular carcinoma cells through impairing PP2A/I2PP2A (Montrer SET Kits ELISA) interaction and stimulating PP2A-dependent p65 (Montrer GORASP1 Kits ELISA) dephosphorylation at Ser536
BIR (Montrer KCNJ11 Kits ELISA) domain of XIAP (Montrer XIAP Kits ELISA) activated the protein phosphatase 2 (PP2A) activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK (Montrer MAPK1 Kits ELISA) kinases/MAPKs, their downstream effector c-Jun (Montrer JUN Kits ELISA); and in turn inhibiting transcription of c-Jun (Montrer JUN Kits ELISA)-regulated miR (Montrer MLXIP Kits ELISA)-200a
T-type channel signaling is redirected towards the activation of the kinase Akt1 (Montrer AKT1 Kits ELISA), leading to increased expression of the anti-apoptotic protein survivin (Montrer BIRC5 Kits ELISA), and a decrease in the pro-apoptotic mediator FoxO3A (Montrer FOXO3 Kits ELISA). Finally, in iPAH cells, Akt1 (Montrer AKT1 Kits ELISA) is no longer able to regulate caspase 9 (Montrer CASP9 Kits ELISA) activation, whereas T-type channel overexpression reverses PP2A defect in iPAH cells but reinforces the deleterious effects of Akt1 (Montrer AKT1 Kits ELISA) activation
The present results indicate that rs959627 predicts PPP2R2 B mRNA prefrontal expression in two independent post-mortem datasets as well as lateral prefrontal activity during working memory in healthy subjects and suggest that genetic modulation of signal transduction mediated by PP2A affects complex biological phenotypes of relevance for cognitive behavior.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon signaling via increased expression of SOCS3 and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (Montrer MAP2K1 Kits ELISA)/ERK (Montrer EPHB2 Kits ELISA)/c-Jun (Montrer JUN Kits ELISA)).
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 (Montrer RASGRF1 Kits ELISA) and DUSP1 (Montrer DUSP1 Kits ELISA)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56
Such effect by miR (Montrer MLXIP Kits ELISA)-429 was again abolished with AMPKalpha1 (Montrer PRKAA1 Kits ELISA) silence or mutation. Together, we propose that PP2A-c silence by miR (Montrer MLXIP Kits ELISA)-429 activates AMPK (Montrer PRKAA1 Kits ELISA) and protects osteoblastic cells from Dex.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A