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Human AXL Kit ELISA pour Sandwich ELISA - ABIN624944
Hsiao, Lin, Hsieh, Chu, Shieh, Hsieh, Lee, Hung: Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. dans The Journal of clinical endocrinology and metabolism 2013
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These results demonstrate that Gas6 (Montrer GAS6 Kits ELISA)/Axl axis confers aggressiveness in breast cancer.
a lower stability and greater dynamic nature of the Axl kinase domain
Silencing AXL or the inhibition of AXL kinase activity significantly inhibits tumor cell migration and invasion in colorectal cancer.
we identify PROS1 (Montrer PROS1 Kits ELISA) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression
Studies indicate that aberrant AXL receptor tyrosine kinase (AXL) signaling and development of an epithelial-to-mesenchymal transition (EMT (Montrer ITK Kits ELISA)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK (Montrer ALK Kits ELISA) F1174L)-driven neuroblastoma (Montrer ARHGEF16 Kits ELISA) (NB) cells to TAE684 and its derivatives.
Studied axl kinase as a negative regulator of an alveolar epithelial cell phenotype; results found that inhibition of Axl kinase could form epithelial adhesion structure and augment surfactant protein production via the MET of human lung multi-potent cells.
AXL is efficiently and sequentially cleaved by alpha- and gamma-secretases in various types of cancer cell lines. The AXL intracellular domain cleavage product translocates into the nucleus via a nuclear localization sequence that harbored a basic HRRKK motif.
a relationship between AXL and the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the DNA-damage markers gammaH2AX (Montrer H2AFX Kits ELISA), 53BP1 (Montrer TP53BP1 Kits ELISA), and RAD51 (Montrer RAD51 Kits ELISA).
Small molecule and antibody inhibitors of AXL and MER (Montrer MERTK Kits ELISA) have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL and MER (Montrer MERTK Kits ELISA) targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.
our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13/MITF (Montrer MITF Kits ELISA)/AXL signal and targeting this newly identified signal with AR degradation enhancer ASC (Montrer PYCARD Kits ELISA)-J9 may help us to better suppress the melanoma metastasis.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (Montrer ERH Kits ELISA) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (Montrer MERTK Kits ELISA) and Tyro3 (Montrer TYRO3 Kits ELISA) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (Montrer ADAM10 Kits ELISA) and TACE (ADAM17 (Montrer ADAM17 Kits ELISA)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (Montrer GAS6 Kits ELISA)/Axl and Akt (Montrer AKT1 Kits ELISA)/FoxO1a (Montrer FOXO1 Kits ELISA) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (Montrer CCNA1 Kits ELISA) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (Montrer CCNA1 Kits ELISA) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
activation of receptor tyrosine kinase (Montrer RET Kits ELISA) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog