anti-Souris EPH Receptor B4 anticorps pour Enzyme Immunoassay

Recommended EPH Receptor B4 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
EPH Receptor B4 (EPHB4) Anticorps
  • htk
  • myk1
  • ephB4a
  • tyro11
  • ephb4b
  • MGC130997
  • AI042935
  • Htk
  • MDK2
  • Myk1
  • Tyro11
  • HTK
  • MYK1
  • TYRO11
  • EPH receptor B4
  • Eph receptor B4
  • EPHB4
  • ephb4-a
  • ephb4
  • LOC100359286
  • Ephb4
Reactivité
Souris
161
67
10
1
1
1
1
Hôte
Rat
70
67
47
20
2
Clonalité
Monoclonal
Conjugué
Cet anticorp EPH Receptor B4 est non-conjugé
8
6
6
5
5
4
4
4
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
140
106
47
28
21
19
6
4
4
4
2
2
2
1
1
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N° du produit ABIN1107116
$ 654.50
Plus shipping costs $45.00

General

Antigène EPH Receptor B4 (EPHB4) Anticorps
Reactivité Souris
(161), (67), (10), (1), (1), (1), (1)
Hôte Rat
(70), (67), (47), (20), (2)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp EPH Receptor B4 est non-conjugé
(8), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(140), (106), (47), (28), (21), (19), (6), (4), (4), (4), (2), (2), (2), (1), (1)
Pubmed 1 référence disponible
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Détail du produit anti-EPH Receptor B4 anticorps

Détail du antigène EPH Receptor B4 Information d'application Stockage References for anti-EPH Receptor B4 antibody (ABIN1107116) Images
Réactivité croisée (Details) Species reactivity (tested):Mouse
Purification Purified
Clone VEB4-7E4
Isotype IgG2a

Détail du antigène EPH Receptor B4

Détail du produit anti-EPH Receptor B4 anticorps Information d'application Stockage References for anti-EPH Receptor B4 antibody (ABIN1107116) Images Haut de la page
Antigène
Autre désignation EPHB4 (EPHB4 Antibody Extrait)
Sujet Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell-extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo's, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well.Synonyms: Ephrin type-B receptor 4, HTK, TYRO11, Tyrosine-protein kinase TYRO11, Tyrosine-protein kinase receptor HTK
ID gène 13846
NCBI Accession NP_034274
UniProt P54761
Pathways Signalisation RTK

Information d'application

Détail du produit anti-EPH Receptor B4 anticorps Détail du antigène EPH Receptor B4 Stockage References for anti-EPH Receptor B4 antibody (ABIN1107116) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-EPH Receptor B4 anticorps Détail du antigène EPH Receptor B4 Information d'application References for anti-EPH Receptor B4 antibody (ABIN1107116) Images Haut de la page
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 2 - 8 °C.

References for anti-EPH Receptor B4 antibody (ABIN1107116)

Détail du produit anti-EPH Receptor B4 anticorps Détail du antigène EPH Receptor B4 Information d'application Stockage Images Haut de la page
Background publications

Huang, Yamada, Kidoya, Naito, Nagahama, Kong, Katoh, Li, Ueno, Takakura: "EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis." dans: Cancer research, Vol. 67, Issue 20, pp. 9800-8, 2007