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Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Engineered multivalency enhanced affibody-mediated HER3 downregulation in multiple cancer cell types.
Both ERBB2 (Montrer ERBB2 Kits ELISA) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (Montrer ERBB2 Kits ELISA) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (Montrer NRG1 Kits ELISA) beta1-induced HIF-1alpha (Montrer HIF1A Kits ELISA) activation in MCF7 cells.
we show that WASF3 (Montrer WASF3 Kits ELISA) is present in the HER2 (Montrer ERBB2 Kits ELISA) immunocomplex and suppression of WASF3 (Montrer WASF3 Kits ELISA) function leads to suppression of invasion even in the presence of HER2 (Montrer ERBB2 Kits ELISA) expression.The engagement of WASF3 (Montrer WASF3 Kits ELISA) with the HER2 (Montrer ERBB2 Kits ELISA)/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (Montrer ERBB2 Kits ELISA)/HER3 activation of JAK (Montrer JAK3 Kits ELISA)/STAT (Montrer STAT1 Kits ELISA) signaling.
This study demonstrates novel regulatory circuits involving miR (Montrer MLXIP Kits ELISA)-148a-3p/ERBB3/AKT2 (Montrer AKT2 Kits ELISA)/c-myc (Montrer MYC Kits ELISA) and DNMT1 (Montrer DNMT1 Kits ELISA) that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
HRG (Montrer NRG1 Kits ELISA)/HER2 (Montrer ERBB2 Kits ELISA)/HER3 signaling promotes AhR (Montrer AHR Kits ELISA)-mediated Memo-1 (Montrer MEMO1 Kits ELISA) expression and migration in colorectal cancer
Simultaneous suppression of ErbB (Montrer EGFR Kits ELISA) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (Montrer EGFR Kits ELISA) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.
Targeting both HER2 (Montrer ERBB2 Kits ELISA) and HER3 resulted in an improved treatment effects on HER2 (Montrer ERBB2 Kits ELISA)-positive gastric cancer.
HER3 is frequently overexpressed in high-grade dysplastic lesions of the gastroesophageal junction and may be a marker of invasive progression
the mechanistic regulation and linkage of the ROR1 (Montrer ROR1 Kits ELISA)-HER3 and Hippo-YAP (Montrer YAP1 Kits ELISA) pathway in a cancer-specific context
Our results support a role for the hepatocellular ERBB (Montrer EGFR Kits ELISA) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (Montrer EGFR Kits ELISA)-ERBB3 DKO models, suggesting that EGFR (Montrer EGFR Kits ELISA)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (Montrer EGFR Kits ELISA) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (Montrer SHH Kits ELISA)) stimulate branching morphogenesis (BrM (Montrer SMARCA2 Kits ELISA)) and induced synthesis of mRNAs for Ptch1 (Montrer PTCH1 Kits ELISA) protein, epidermal growth factor (EGF (Montrer EGF Kits ELISA)) and receptors of the ErbB (Montrer EGFR Kits ELISA) receptors ErbB1 (Montrer EGFR Kits ELISA), ErbB2 (Montrer ERBB2 Kits ELISA) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (Montrer ERBB4 Kits ELISA) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (Montrer AKT1 Kits ELISA) pathway and promoting erbB2 (Montrer ERBB2 Kits ELISA)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (Montrer STAT3 Kits ELISA) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase