anti-Rat (Rattus) FGFR4 anticorps pour Immunohistochemistry (Paraffin-embedded Sections)

Recommended FGFR4 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Fibroblast Growth Factor Receptor 4 (FGFR4) Anticorps
  • FGFR4
  • XFGFR-4
  • XFGFR-4a
  • cd334
  • fgfr-4
  • jtk2
  • tkf
  • xfgfr4
  • CD334
  • JTK2
  • TKF
  • Fgfr-4
  • etID309818.21
  • wu:fc13h10
  • zgc:111935
  • fgfr-4c
  • fgfr4
  • fibroblast growth factor receptor 4
  • FGFR4
  • fgfr4
  • Fgfr4
  • fgfr4-b
Épitope
AA 40-90
20
18
15
13
9
8
7
6
6
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
207
55
44
3
3
Hôte
Lapin
126
69
27
1
Clonalité
Polyclonal
Conjugué
Cet anticorp FGFR4 est non-conjugé
8
8
7
4
4
4
4
4
4
4
3
3
3
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
155
97
55
48
34
29
12
9
9
6
4
3
2
2
1
1
Options
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N° du produit ABIN671766
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN2001665 ELISA IHC (p) Rabbit IgG AA 1-367 Connectez-vous pour afficher Polyclonal
1 ABIN671775 IHC (p) WB HRP Rabbit IgG AA 40-90 Connectez-vous pour afficher Polyclonal
1 ABIN671768 IHC (p) WB Biotin Rabbit IgG AA 40-90 Connectez-vous pour afficher Polyclonal

General

Antigène Fibroblast Growth Factor Receptor 4 (FGFR4) Anticorps
Épitope AA 40-90
(20), (18), (15), (13), (9), (8), (7), (6), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(207), (55), (44), (3), (3)
Hôte Lapin
(126), (69), (27), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp FGFR4 est non-conjugé
(8), (8), (7), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(155), (97), (55), (48), (34), (29), (12), (9), (9), (6), (4), (3), (2), (2), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-FGFR4 anticorps

Détail du antigène FGFR4 Information d'application Stockage Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from human FGFR4
Isotype IgG

Détail du antigène FGFR4

Détail du produit anti-FGFR4 anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation FGFR4/CD334 (FGFR4 Antibody Extrait)
Sujet

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Subcellular location: Extracellular

Synonyms: TKF, JTK2, CD334, Fibroblast growth factor receptor 4, FGFR-4, FGFR4

ID gène 2264
UniProt P22455
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding

Information d'application

Détail du produit anti-FGFR4 anticorps Détail du antigène FGFR4 Stockage Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-FGFR4 anticorps Détail du antigène FGFR4 Information d'application Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

Images

Détail du produit anti-FGFR4 anticorps Détail du antigène FGFR4 Information d'application Stockage Haut de la page
Supplier Images
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 40-90) antibody (ABIN671766) Formalin-fixed and paraffin embedded rat brain labeled Anti-FGFR4 Polyclonal Antibody...
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 40-90) antibody (ABIN671766) Formalin-fixed and paraffin embedded human cervical carcinoma labeled Anti-FGFR4 Poly...