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anti-Mouse (Murine) NFAT1 Anticorps:
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Human Monoclonal NFAT1 Primary Antibody pour ChIP, ELISA - ABIN152663
Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. dans Proceedings of the National Academy of Sciences of the United States of America 2007
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Dog (Canine) Monoclonal NFAT1 Primary Antibody pour IF, IP - ABIN968123
Boise, Petryniak, Mao, June, Wang, Lindsten, Bravo, Kovary, Leiden, Thompson: The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. dans Molecular and cellular biology 1993
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Dog (Canine) Monoclonal NFAT1 Primary Antibody pour IF, IP - ABIN968124
Good, Maggirwar, Harhaj, Sun: Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. dans The Journal of biological chemistry 1997
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Cow (Bovine) Polyclonal NFAT1 Primary Antibody pour WB - ABIN2779960
Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. dans Blood 2005
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Human Monoclonal NFAT1 Primary Antibody pour IF, IP - ABIN967558
Crabtree: Contingent genetic regulatory events in T lymphocyte activation. dans Science (New York, N.Y.) 1989
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Human Polyclonal NFAT1 Primary Antibody pour IHC, IHC (p) - ABIN4339296
Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. dans Cell death & disease 2015
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Human Polyclonal NFAT1 Primary Antibody pour ELISA, IHC - ABIN4339294
Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. dans Annals of the New York Academy of Sciences 2007
Human Polyclonal NFAT1 Primary Antibody pour ICC, IF - ABIN4339295
Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. dans Oncogene 2016
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (Montrer NFKB1 Anticorps)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (Montrer CD4 Anticorps)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (Montrer CCNE1 Anticorps) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (Montrer NFATC1 Anticorps) in mouse islets enhanced insulin (Montrer INS Anticorps) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (Montrer INS Anticorps) secretion vs. b-cell proliferation are regulated by NFAT (Montrer NFATC1 Anticorps)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (Montrer CD4 Anticorps)(+)/CD8 (Montrer CD8A Anticorps)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (Montrer HSF1 Anticorps)-mediated maintenance of whole body homeostasis
NFAT (Montrer NFATC1 Anticorps) directs signaling enzymes to gene promoters in islets.
FOXP3 (Montrer FOXP3 Anticorps) can inhibit NFAT (Montrer NFATC1 Anticorps) driven expression of CD40L (Montrer CD40LG Anticorps) and IL-17 (Montrer IL17A Anticorps) in CD4 (Montrer CD4 Anticorps) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
our findings reveal a new signaling pathway in microglia that couples TLR4 (Montrer TLR4 Anticorps) activation with the translocation of NFAT1 into mitochondria to control the microglial activation during brain infection.
An interaction of NFAT1 and the beta-catenin (Montrer CTNNB1 Anticorps) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (Montrer CTNNB1 Anticorps)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (Montrer CA2 Anticorps)+ microdomains, whereas NFAT4 (Montrer NFATC3 Anticorps) additionally requires Ca2 (Montrer CA2 Anticorps)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
revealed more than 170 NFAT (Montrer NFATC1 Anticorps)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (Montrer NFATC1 Anticorps) and NFATc2 in T cells, such as Raptor (Montrer RPTOR Anticorps), CHEK1 (Montrer CHEK1 Anticorps), CREB1 (Montrer CREB1 Anticorps), RUNX1 (Montrer RUNX1 Anticorps), SATB1 (Montrer SATB1 Anticorps), Ikaros (Montrer IKZF1 Anticorps), and Helios (Montrer ZNFN1A2 Anticorps).
NFAT1 silencing could suppress cell migration and invasion through MMP-3 (Montrer MMP3 Anticorps).
FOXP1 (Montrer FOXP1 Anticorps) has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity.
we describe a novel mechanism by which GSK-3beta (Montrer GSK3b Anticorps) fine-tunes NFATc2 and STAT3 (Montrer STAT3 Anticorps) transcriptional networks to integrate upstream signaling events that govern pancreatic cancer progression and growth.
Up-regulation of Store-operated Ca2 (Montrer CA2 Anticorps)+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells.
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
, nuclear factor of activated T-cells, cytoplasmic 2-like
, NFAT pre-existing subunit
, T-cell transcription factor NFAT1
, nuclear factor of activated T-cells, cytoplasmic 2
, NFAT transcription complex, preexisting component
, T cell transcription factor NFAT1
, nuclear factor of activated T-cells, preexisting component
, preexisting nuclear factor of activated T-cells 2