anti-Humain NFATC1 anticorps pour Flow Cytometry

Recommended NFATC1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Anticorps
  • nf-atc
  • nfat2
  • nfatc
  • si:ch211-198c22.2
  • NFATC1
  • 2210017P03Rik
  • AI449492
  • AV076380
  • NF-ATc
  • NFAT2
  • NFATc
  • Nfatcb
  • NF-ATC
  • NF-ATc1
  • NFAT
  • NFATmac
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  • NFATC1
  • nfatc1
  • Nfatc1
Épitope
AA 197-304
29
20
15
14
13
7
6
6
6
5
5
4
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
152
55
39
10
7
7
7
5
4
4
3
3
1
1
1
1
1
Hôte
Souris
105
46
1
Clonalité
Monoclonal
Conjugué
Cet anticorp NFATC1 est conjugé à/à la Alexa Fluor 488
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS)
124
53
48
16
13
11
11
9
6
4
3
3
2
2
2
1
1
Fournisseur
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N° du produit ABIN2657092
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
14.320307 ABIN2662815 FACS PE Mouse IgG1 AA 197-304 Connectez-vous pour afficher 7A6 7
1 ABIN2666355 FACS Mouse IgG1 AA 197-304 Connectez-vous pour afficher 7A6 8
1 ABIN2657093 CyTOF FACS Alexa Fluor 488 Mouse IgG1 AA 197-304 Connectez-vous pour afficher 7A6 7
1 ABIN2662816 FACS PE Mouse IgG1 AA 197-304 Connectez-vous pour afficher 7A6 7
1 ABIN2666356 FACS Mouse IgG1 AA 197-304 Connectez-vous pour afficher 7A6 8
1 ABIN233537 GS ICC FACS IP WB Mouse IgG1 AA 1-654 Connectez-vous pour afficher

General

Antigène Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Anticorps
Épitope AA 197-304
(29), (20), (15), (14), (13), (7), (6), (6), (6), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(152), (55), (39), (10), (7), (7), (7), (5), (4), (4), (3), (3), (1), (1), (1), (1), (1)
Hôte Souris
(105), (46), (1)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp NFATC1 est conjugé à/à la Alexa Fluor 488
(5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS)
(124), (53), (48), (16), (13), (11), (11), (9), (6), (4), (3), (3), (2), (2), (2), (1), (1)
Pubmed 7 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-NFATC1 anticorps

Détail du antigène NFATC1 Information d'application Stockage ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Images
Purification The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone 7A6
Isotype IgG1

Détail du antigène NFATC1

Détail du produit anti-NFATC1 anticorps Information d'application Stockage ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Images Haut de la page
Antigène
Autre désignation NFATc1 (NFATC1 Antibody Extrait)
Sujet The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. The protein complex consists of NFAT1, NFAT2 (NFATc1 or NFATc), NFAT3, and NFAT4. All members of this family are transcription factors with a Rel homology domain and regulate gene transcription in concert with AP-1 (Jun/Fos) to orchestrate an effective immune response. NFAT proteins are predominantly expressed in cells of the immune system but are also expressed in skeletal muscle, keratinocytes and adipocytes, regulating cell differentiation programs in these cells. In resting cells, NFAT proteins are heavily phosphorylated and localized in the cytoplasm. Increased intracellular calcium concentrations activate the calcium/calmodulin-dependent serine phosphatase calcineurin, which dephosphorylates NFAT proteins, resulting in their subsequent translocation to the nucleus. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Domaine de recherche Signaling
Pathways Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway

Information d'application

Détail du produit anti-NFATC1 anticorps Détail du antigène NFATC1 Stockage ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-NFATC1 anticorps Détail du antigène NFATC1 Information d'application ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Images Haut de la page
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C

ProductDetails: References for anti-NFATC1 antibody (ABIN2657092)

Détail du produit anti-NFATC1 anticorps Détail du antigène NFATC1 Information d'application Stockage Images Haut de la page
Background publications

Zhao, Wang, Liu, He, Jia: "NFATc1: functions in osteoclasts." dans: The international journal of biochemistry & cell biology, Vol. 42, Issue 5, pp. 576-9, 2010

Brandt, Liman, Bendfeldt, Mueller, Reinke, Radbruch, Worm, Baumgrass: "Whole blood flow cytometric measurement of NFATc1 and IL-2 expression to analyze cyclosporine A-mediated effects in T cells." dans: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 77, Issue 7, pp. 607-13, 2010

Serfling, Berberich-Siebelt, Avots: "NFAT in lymphocytes: a factor for all events?" dans: Science's STKE : signal transduction knowledge environment, Vol. 2007, Issue 398, pp. pe42, 2007

Hogan, Chen, Nardone, Rao: "Transcriptional regulation by calcium, calcineurin, and NFAT." dans: Genes & development, Vol. 17, Issue 18, pp. 2205-32, 2003

Timmerman, Healy, Ho, Chen, Goodnow, Crabtree: "Redundant expression but selective utilization of nuclear factor of activated T cells family members." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 6, pp. 2735-40, 1997

Hoey, Sun, Williamson, Xu: "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins." dans: Immunity, Vol. 2, Issue 5, pp. 461-72, 1995

Northrop, Ullman, Crabtree: "Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex." dans: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2917-23, 1993

Images

Détail du produit anti-NFATC1 anticorps Détail du antigène NFATC1 Information d'application Stockage ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Haut de la page
Supplier Images
Flow Cytometry (FACS) image for anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) (AA 197-304) antibody (Alexa Fluor 488) (ABIN2657092) anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) (AA 197-304) antibody (Alexa Fluor 488)