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Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (Montrer OPN1MW Kits ELISA) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (Montrer AKAP5 Kits ELISA)/PP2B (Montrer CAN Kits ELISA)/protein kinase A complex's role in synaptic long-term depression in the CA1 (Montrer CA1 Kits ELISA) region of the hippocampus.
Ca(2 (Montrer CA2 Kits ELISA)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (Montrer NFATC1 Kits ELISA)) c4 axis is required for neuritin (Montrer NRN1 Kits ELISA)-induced Kv4.2 (Montrer KCND2 Kits ELISA) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (Montrer CABIN1 Kits ELISA) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (Montrer NPHS1 Kits ELISA).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (Montrer DNM1L Kits ELISA)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (Montrer NFATC1 Kits ELISA) occurs via a phagosomal TLR9 (Montrer TLR9 Kits ELISA)-dependent and Bruton's tyrosine kinase (Montrer BTK Kits ELISA)-dependent signalling pathway that is independent of MyD88 (Montrer MYD88 Kits ELISA)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB.
Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (Montrer NFATC1 Kits ELISA) (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 (Montrer IL2 Kits ELISA) gene transcription.
these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (Montrer NFATC1 Kits ELISA) pathway regulates development and function of IFN-gamma (Montrer IFNG Kits ELISA)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (Montrer RCAN1 Kits ELISA) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (Montrer NPHS1 Kits ELISA) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (Montrer PPP3CB Kits ELISA), and tissue-specific ablation of regulatory subunit Ppp3r1 (Montrer PPP3R1 Kits ELISA) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB (Montrer NFKB1 Kits ELISA)-inducing kinase (NIK (Montrer MAP4K4 Kits ELISA)) and attenuate NIK (Montrer MAP4K4 Kits ELISA)-dependent gene expression
Data indicate that calcineurin (CnAalpha-/- or CnAbeta (Montrer PPP3CB Kits ELISA)-/-) is required for pathological but not compensatory renal hypertrophy.
The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation
CAM-PRP catalytic subunit
, calcineurin A alpha
, calmodulin-dependent calcineurin A subunit alpha isoform
, protein phosphatase 2B, catalytic subunit, alpha isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
, PP2B alpha 1
, PP2BA alpha
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
, protein phosphatase 3, catalytic subunit, alpha isoform
, Calcineurin subunit A alpha
, protein phosphatase-2Ba
, calcineurin catalytic subunit delta isoform
, calcineurin catalytic subunit
, protein phosphatase 3, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like