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The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels.
The mRNA expressions of PPP3CB (Montrer PPP3CB Kits ELISA) and MEF2C (Montrer MEF2C Kits ELISA) were significantly up-regulated, and CAMK1 (Montrer CAMK1 Kits ELISA) and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (Montrer PPP3CB Kits ELISA), MEF2C (Montrer MEF2C Kits ELISA) and PLCE1 (Montrer PLCE1 Kits ELISA) compared to aortic valve disease patients
we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (Montrer TLR4 Kits ELISA)/MD2 (Montrer LY96 Kits ELISA) complex together with the co-receptor CD14 (Montrer NDUFA2 Kits ELISA)
CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 (Montrer TLR4 Kits ELISA) signaling through TRAF3 (Montrer TRAF3 Kits ELISA) and TRAF6 (Montrer TRAF6 Kits ELISA), in response to various agonists.
Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B.
Further evidence that specific variations in MAPT (Montrer MAPT Kits ELISA) (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease
Expression level of PPP3R1 and GATA4 (Montrer GATA4 Kits ELISA), and NFATC4 (Montrer NFATC4 Kits ELISA) genes for transcription factors did not differ in studied subgroups of patients.
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (Montrer NFATC1 Kits ELISA) targets required for replication, insulin (Montrer INS Kits ELISA) storage, and secretion.
These findings reveal a novel signaling pathway (CnB-CD11b (Montrer ITGAM Kits ELISA)-NF-kappaB (Montrer NFKB1 Kits ELISA)-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.
CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells.
global deficiency of catalytic subunit Ppp3cb (Montrer PPP3CB Kits ELISA), and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors.
Macrophage Wnt (Montrer WNT2 Kits ELISA)-Calcineurin-Flt1 (Montrer FLT1 Kits ELISA) signaling regulates mouse wound angiogenesis and repair.
intact calcineurin/NFAT (Montrer NFATC1 Kits ELISA) signalling is critically required for p53 (Montrer TP53 Kits ELISA) and senescence-associated mechanisms that protect against skin squamous cancer development
Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2 (Montrer CA2 Kits ELISA)+)-handling genes that likely lead to arrhythmia and reduced contractility
Calcineurin B1 is essential for positive selection during thymocyte development.
gene expression of peroxisome proliferator-activated receptor gamma (Montrer PPARG Kits ELISA) coactivator 1alpha and peroxisome proliferator-activated receptor alpha (Montrer PPARA Kits ELISA) was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit.
interconnection exists between Notch 1 (Montrer NOTCH1 Kits ELISA) and Calcineurin-NFAT (Montrer NFATC1 Kits ELISA) pathways in keratinocyte growth/differentiation control
The calcineurin/Nfat (Montrer NFATC1 Kits ELISA) pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
, calcineurin subunit B type 1
, protein phospatase 3 regulatory subunit B alpha isoform type 1
, protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
, calcineurin B, type I (19kDa)
, protein phosphatase 2B regulatory subunit 1
, protein phosphatase 2B regulatory subunit B alpha
, protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
, calcineurin B
, protein phosphatase 3 regulatory subunit B alpha
, protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, protein phospatase 3, regulatory subunit B, alpha isoform,type 1
, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, PP2B beta 1