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anti-Human SHC3 Anticorps:
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Human Polyclonal SHC3 Primary Antibody pour WB - ABIN2801960
Liu, Meakin: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. dans The Journal of biological chemistry 2002
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Human Monoclonal SHC3 Primary Antibody pour IF, IP - ABIN968083
Conti, Sipione, Magrassi, Bonfanti, Rigamonti, Pettirossi, Peschanski, Haddad, Pelicci, Milanesi, Pelicci, Cattaneo: Shc signaling in differentiating neural progenitor cells. dans Nature neuroscience 2001
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Human Monoclonal SHC3 Primary Antibody pour IF, IP - ABIN968082
OBryan, Songyang, Cantley, Der, Pawson: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. dans Proceedings of the National Academy of Sciences of the United States of America 1996
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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (Montrer SHC1 Anticorps)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (Montrer RNH1 Anticorps) and CD3EAP (Montrer CD3EAP Anticorps) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (Montrer S1PR3 Anticorps) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (Montrer SHC1 Anticorps).
ALK (Montrer ALK Anticorps)-ShcC signal activation, possibly caused by co-amplification with the N-myc (Montrer MYCN Anticorps) gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK (Montrer ALK Anticorps) kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (Montrer RET Anticorps) to the phosphatidylinositol 3-kinase/Akt (Montrer AKT1 Anticorps) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (Montrer ARHGEF16 Anticorps) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (Montrer SHC1 Anticorps))is a critical substrate for RET (Montrer RET Anticorps) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (Montrer ZAP70 Anticorps) to the phosphorylated subunit of the TCR/CD3 (Montrer CD3E Anticorps) complex.
TrkB (Montrer NTRK2 Anticorps)-mediated ERK1/2 (Montrer MAPK1/3 Anticorps) activation is impaired in huntingtin (Montrer HTT Anticorps) knock-in striatal cells involves reduced p52 (Montrer GTF2H4 Anticorps)/p46 (Montrer POLDIP3 Anticorps) Shc (Montrer SHC1 Anticorps) expression
binds the Trk (Montrer NTRK1 Anticorps) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (Montrer NTRK2 Anticorps)-Ras/MAPK (Montrer MAPK1 Anticorps) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3