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anti-Human SHC3 Anticorps:
anti-Rat (Rattus) SHC3 Anticorps:
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Human Polyclonal SHC3 Primary Antibody pour WB - ABIN2801960
Liu, Meakin: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. dans The Journal of biological chemistry 2002
Show all 4 references for ABIN2801960
Human Monoclonal SHC3 Primary Antibody pour IF, IP - ABIN968082
Conti, Sipione, Magrassi, Bonfanti, Rigamonti, Pettirossi, Peschanski, Haddad, Pelicci, Milanesi, Pelicci, Cattaneo: Shc signaling in differentiating neural progenitor cells. dans Nature neuroscience 2001
Show all 3 references for ABIN968082
Human Polyclonal SHC3 Primary Antibody pour IHC, ELISA - ABIN1535370
Nakamura, Sanokawa, Sasaki, Ayusawa, Oishi, Mori: N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. dans Oncogene 1996
Show all 2 references for ABIN1535370
Human Polyclonal SHC3 Primary Antibody pour WB - ABIN2786992
Villanacci, Bassotti, Ortensi, Fisogni, Cathomas, Maurer, Galletti, Salerni, Pelicci: Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system. dans Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2008
High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (Montrer SHC1 Anticorps)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (Montrer RNH1 Anticorps) and CD3EAP (Montrer CD3EAP Anticorps) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (Montrer S1PR3 Anticorps) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (Montrer SHC1 Anticorps).
ALK (Montrer ALK Anticorps)-ShcC signal activation, possibly caused by co-amplification with the N-myc (Montrer MYCN Anticorps) gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK (Montrer ALK Anticorps) kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (Montrer RET Anticorps) to the phosphatidylinositol 3-kinase/Akt (Montrer AKT1 Anticorps) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (Montrer ARHGEF16 Anticorps) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (Montrer SHC1 Anticorps))is a critical substrate for RET (Montrer RET Anticorps) oncoproteins in thyroid carcinomas
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (Montrer ZAP70 Anticorps) to the phosphorylated subunit of the TCR/CD3 (Montrer CD3E Anticorps) complex.
TrkB (Montrer NTRK2 Anticorps)-mediated ERK1/2 (Montrer MAPK1/3 Anticorps) activation is impaired in huntingtin (Montrer HTT Anticorps) knock-in striatal cells involves reduced p52 (Montrer GTF2H4 Anticorps)/p46 (Montrer POLDIP3 Anticorps) Shc (Montrer SHC1 Anticorps) expression
binds the Trk (Montrer NTRK1 Anticorps) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (Montrer NTRK2 Anticorps)-Ras/MAPK (Montrer MAPK1 Anticorps) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
study reports co-localization of adaptor proteins nShc & Grb10 (Montrer GRB10 Anticorps), with Kv1.3 (Montrer KCNA3 Anticorps) channel in the olfactory bulb neural lamina; BDNF (Montrer BDNF Anticorps)-induced current suppression of the Kv1.3 (Montrer KCNA3 Anticorps) channel was prevented by both nShc and Grb10 (Montrer GRB10 Anticorps)
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3