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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (Montrer SHC1 Kits ELISA)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (Montrer S1PR3 Kits ELISA) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (Montrer SHC1 Kits ELISA).
ALK (Montrer ALK Kits ELISA)-ShcC signal activation, possibly caused by co-amplification with the N-myc (Montrer MYCN Kits ELISA) gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK (Montrer ALK Kits ELISA) kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (Montrer RET Kits ELISA) to the phosphatidylinositol 3-kinase/Akt (Montrer AKT1 Kits ELISA) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (Montrer ARHGEF16 Kits ELISA) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (Montrer SHC1 Kits ELISA))is a critical substrate for RET (Montrer RET Kits ELISA) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (Montrer ZAP70 Kits ELISA) to the phosphorylated subunit of the TCR/CD3 (Montrer CD3E Kits ELISA) complex.
TrkB (Montrer NTRK2 Kits ELISA)-mediated ERK1/2 (Montrer MAPK1/3 Kits ELISA) activation is impaired in huntingtin (Montrer HTT Kits ELISA) knock-in striatal cells involves reduced p52/p46 (Montrer POLDIP3 Kits ELISA) Shc (Montrer SHC1 Kits ELISA) expression
binds the Trk (Montrer NTRK1 Kits ELISA) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (Montrer NTRK2 Kits ELISA)-Ras/MAPK (Montrer MAPK1 Kits ELISA) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3