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anti-Human TYRO3 Anticorps:
anti-Rat (Rattus) TYRO3 Anticorps:
anti-Mouse (Murine) TYRO3 Anticorps:
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Human Monoclonal TYRO3 Primary Antibody pour FACS - ABIN4897539
Gould, Baxi, Schroeder, Peng, Leadley, Peterson, Perrin: Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. dans Journal of thrombosis and haemostasis : JTH 2005
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Human Monoclonal TYRO3 Primary Antibody pour IF, ELISA - ABIN967221
Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: A novel putative tyrosine kinase receptor with oncogenic potential. dans Oncogene 1991
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Mouse (Murine) Monoclonal TYRO3 Primary Antibody pour CyTOF, ELISA (Capture) - ABIN4900191
Fujimori, Grabiec, Kaur, Bell, Fujino, Cook, Svedberg, MacDonald, Maciewicz, Singh, Hussell: The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. dans Mucosal immunology 2015
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Human Monoclonal TYRO3 Primary Antibody pour ICC, ELISA - ABIN1724702
Hafizi, Gustafsson, Stenhoff, Dahlbäck: The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. dans The international journal of biochemistry & cell biology 2005
Human Polyclonal TYRO3 Primary Antibody pour FACS, ICC - ABIN440474
Chan, Carrera Silva, De Kouchkovsky, Joannas, Hao, Hu, Huntsman, Eng, Licona-Limón, Weinstein, Herbert, Craft, Flavell, Repetto, Correale, Burchard, Torgerson, Ghosh, Rothlin: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. dans Science (New York, N.Y.) 2016
Human Monoclonal TYRO3 Primary Antibody pour ELISA, WB - ABIN967222
Heiring, Dahlbäck, Muller: Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family. dans The Journal of biological chemistry 2004
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Human Monoclonal TYRO3 Primary Antibody pour ELISA, WB - ABIN969449
Lan, Wu, Li, Wu, Lu, Xu, Dai: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. dans Blood 2000
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (Montrer MERTK Anticorps) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (Montrer MERTK Anticorps) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (Montrer ITK Anticorps) through the regulation of SNAI1 (Montrer SNAI1 Anticorps).
In this paper, we review the biology of the Gas6 (Montrer GAS6 Anticorps)/Tyro3, Axl (Montrer AXL Anticorps), and MerTK (Montrer MERTK Anticorps)(collectively named TAM (Montrer CCNA1 Anticorps) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (Montrer MERTK Anticorps)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE (Montrer RPE Anticorps) phagocytosis, and suggest that an eQTL (Montrer EQTN Anticorps) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3, Axl (Montrer AXL Anticorps) were decreased in pSS (Montrer CDSN Anticorps) patients. When considering the plasma level, increased levels of soluble Mer (Montrer MERTK Anticorps) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (Montrer RET Anticorps) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (Montrer ROS1 Anticorps)-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt (Montrer AKT1 Anticorps).
Tetherin (Montrer BST2 Anticorps) phosphorylation induces the recruitment of Syk (Montrer SYK Anticorps) which is required for downstream NF-kappaB (Montrer NFKB1 Anticorps) activation.
These studies demonstrate that, despite their similarity, TYRO3, AXL, and MER are likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs.
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (Montrer AXL Anticorps), Mertk (Montrer MERTK Anticorps) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (Montrer ERBB3 Anticorps) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (Montrer CCNA1 Anticorps) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (Montrer CCNA1 Anticorps) signaling requires coincident TAM (Montrer CCNA1 Anticorps) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (Montrer CCNA1 Anticorps) receptor tyrosine kinases Tyro3, Axl (Montrer AXL Anticorps), and Mer (Montrer ERH Anticorps) and their ligands Gas6 (Montrer GAS6 Anticorps) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
Axl (Montrer AXL Anticorps) and Mer (Montrer ERH Anticorps) (TAM (Montrer CCNA1 Anticorps)) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl (Montrer AXL Anticorps)(-/-)Mer (Montrer ERH Anticorps)(-/-) triple mutant (TAM (Montrer CCNA1 Anticorps)(-/-)) mice exhibited chronic hepatitis
Adult brain neurogenesis is reduced in the hippocampus of the Tyro3-/-Axl (Montrer AXL Anticorps)-/-Mertk (Montrer MERTK Anticorps)-/- triple-knockout but not in single Tyro3-/- knockouts.
Chronic systemic inflammation and autoimmune disorders in the Tyro3, Axl (Montrer AXL Anticorps) and Mertk (Montrer MERTK Anticorps) knockout mice cause neuronal damage and death.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase