anti-Souris LEF1 anticorps pour Immunofluorescence

Recommended LEF1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Lymphoid Enhancer-Binding Factor 1 (LEF1) Anticorps
  • LEF1
  • 3000002B05
  • AI451430
  • Lef-1
  • LEF-1
  • TCF10
  • TCF1ALPHA
  • TCF7L3
  • lymphoid enhancer-binding factor 1
  • lymphocyte enhancer binding factor 1
  • lymphoid enhancer binding factor 1
  • lymphoid enhancer factor XLEF-1B
  • LEF1
  • LOC100352691
  • lef1
  • Lef1
Épitope
HMG Binding Domain
15
13
13
9
8
6
6
6
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
128
41
32
11
7
7
5
5
4
4
4
4
3
2
1
1
Hôte
Souris
57
51
16
5
Clonalité
Monoclonal
Conjugué
Cet anticorp LEF1 est non-conjugé
3
3
3
3
3
3
Application
Immunofluorescence (IF), Western Blotting (WB)
115
67
21
17
10
7
5
3
2
2
2
1
1
1
1
Fournisseur
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N° du produit ABIN264381
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN221435 ICC FACS IF IP WB Rabbit IgG Pro82 Connectez-vous pour afficher
1 ABIN264379 IF IHC (p) WB Mouse IgG1 Connectez-vous pour afficher REMB1

General

Antigène Lymphoid Enhancer-Binding Factor 1 (LEF1) Anticorps
Épitope HMG Binding Domain
(15), (13), (13), (9), (8), (6), (6), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris
(128), (41), (32), (11), (7), (7), (5), (5), (4), (4), (4), (4), (3), (2), (1), (1)
Hôte Souris
(57), (51), (16), (5)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp LEF1 est non-conjugé
(3), (3), (3), (3), (3), (3)
Application Immunofluorescence (IF), Western Blotting (WB)
(115), (67), (21), (17), (10), (7), (5), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 référence disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-LEF1 anticorps

Détail du antigène LEF1 Information d'application Stockage References for anti-LEF1 antibody (ABIN264381) Images
Specificité REMB6 recognizes the High Mobility Group DNA domain of LEF-1.
Attributs du produit Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha,TCF1-alpha
Purification Purified
Immunogène Full-length recombinant LEF-1 protein. Genename: LEF1
Clone REMB6
Isotype IgG1

Détail du antigène LEF1

Détail du produit anti-LEF1 anticorps Information d'application Stockage References for anti-LEF1 antibody (ABIN264381) Images Haut de la page
Antigène
Autre désignation LEF1 (LEF1 Antibody Extrait)
Sujet Lymphoid Enhancer Factor-1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3 and TCF-4). These factors play a crucial role in WNT/WIngless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.LEF-1 is expressed during development in many different differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers and the trigeminal nerve. It is redundant with TCF-1 (for T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of polypeptides ranging in size between 55-57 kD on SDS-PAGE analysis. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They can appear on westerns as smaller immunoreactive forms.Synonyms: LEF-1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha
ID gène 51176
UniProt Q9UJU2
Domaine de recherche Transcription Factors, Wnt, Lineage Markers, Wnt Signaling
Pathways Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding

Information d'application

Détail du produit anti-LEF1 anticorps Détail du antigène LEF1 Stockage References for anti-LEF1 antibody (ABIN264381) Images Haut de la page
Indications d'application Western Blot: 1-5 μg/mLImmunofluorescence on Paraformaldehyde-Fixed Cells: 1 μg/mL (1/1000). Positive Control: Jurkat cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Stockage

Détail du produit anti-LEF1 anticorps Détail du antigène LEF1 Information d'application References for anti-LEF1 antibody (ABIN264381) Images Haut de la page
Buffer PBS, 0.08 % Sodium Azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Date de péremption 12 months

References for anti-LEF1 antibody (ABIN264381)

Détail du produit anti-LEF1 anticorps Détail du antigène LEF1 Information d'application Stockage Images Haut de la page
Background publications

Hsu, Galceran, Grosschedl: "Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin." dans: Molecular and cellular biology, Vol. 18, Issue 8, pp. 4807-18, 1998

Images

Détail du produit anti-LEF1 anticorps Détail du antigène LEF1 Information d'application Stockage References for anti-LEF1 antibody (ABIN264381) Haut de la page
Supplier Images
Western Blotting (WB) image for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (ABIN264381) anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody
Immunofluorescence (IF) image for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (ABIN264381) anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (Image 2)