Aperçu des produits pour LRP5 Protéines (LRP5)

Full name:
Low Density Lipoprotein Receptor-Related Protein 5 Protéines (LRP5)
Chez www.anticorps-enligne.fr sont 10 Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Protéines de 4 de différents fournisseurs disponibles. De plus, nous expédions LRP5 Anticorps (128) et LRP5 Kits (13) et beaucoup plus de produits pour cette protéine. Un total de 154 LRP5 produits sont actuellement listés.
Synonymes:
BMND1, EVR1, EVR4, HBM, LR3, LRP5, lrp5-A, LRP6, LRP7, mKIAA4142, OPPG, OPS, OPTA1, VBCH2, Xlrp5
afficher tous les protéines Gène GeneID UniProt
LRP5 4041 O75197
LRP5 16973 Q91VN0
LRP5 293649  

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LRP5 Protéines (LRP5) par origine

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Plus protéines pour LRP5 partenaires d'interaction

Xenopus laevis Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. The extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt (Montrer WNT2 Protéines) signaling during Xenopus and mouse development in vivo.

Zebrafish Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. Data show that in zebrafish, lrp5 also controls cell migration during early morphogenetic processes and contributes to shaping the craniofacial skeleton.

Human Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (Montrer NDP Protéines) (3/31, 9.7%), FZD4 (Montrer FZD4 Protéines) (2/31, 6.5%), TSPAN12 (Montrer TSPAN12 Protéines) (1/31, 3.2%), and KIF11 (Montrer KIF11 Protéines) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  2. wild-type and all five mutant LRP5 proteins were assayed for the ability to activate the Norrin (Montrer NDP Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathway by established luciferase reporter assays, and all mutants failed to activate the pathway.

  3. findings revealed an unrecognized role of Caprin-2 (Montrer CAPRIN2 Protéines) in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (Montrer CDK14 Protéines), Cyclin Y (Montrer CCNY Protéines), and LRP5/6.

  4. This study did not identify LRP5 polymorphisms as a risk factor for osteoporosis in Thai menopausal women.

  5. We identified four novel LRP5 missense mutations in these FEVR (Montrer NDP Protéines) families: c.C1042T (p.R348W), c.G1141A (p.D381N), c.C1870T (p.R624W), and c.A4550G (p.Y1517C). All four of these LRP5 mutations led to significant reduction of enzymatic activity with response to NORRIN (Montrer NDP Protéines). Our findings expand the mutational spectrum of FEVR (Montrer NDP Protéines) in the Indian population and provide some guidelines in clinical diagnosis.

  6. In this study, the splice site mutation c.2827thorn1G > A found in LRP5 (603506) gene is thought to cause microphthalmia in this family.

  7. A genetic evaluation of the known genes associated with familial exudative vitreoretinopathy (FEVR (Montrer NDP Protéines)) revealed a novel variant in the LRP5 gene that co-segregated with the phenotype in the family.

  8. Meta-analysis indicates that the LRP5 Ala1330Val polymorphism may not be correlated with fracture susceptibility.

  9. Independently or combined with APOE (Montrer APOE Protéines), LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.

  10. miR (Montrer MLXIP Protéines)-23a plays an inhibitory role in osteogenic differentiation of hBMSCs, which may act by targeting LRP5

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. we revealed miR (Montrer MLXIP Protéines)-375-3p negatively regulated osteogenesis by targeting LRP5 and beta-catenin (Montrer CTNNB1 Protéines)

  2. lung myeloid cells are responsive to Lrp5/beta-catenin (Montrer CTNNB1 Protéines) signaling, leading to differentiation of an alveolar macrophage subtype that antagonizes the resolution of lung fibrosis.

  3. LRP5 is a novel anti-inflammatory macrophage marker that positively regulates migration, phagocytosis, lipid uptake and metabolism.

  4. These results revealed a new role of the canonical Lrp5/6-beta-catenin (Montrer CTNNB1 Protéines) pathway in regulating the morphogenesis of the cerebellum during postnatal development.

  5. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels.

  6. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture.

  7. Data show that LDL receptor (Montrer LDLR Protéines)-related protein 5 (Montrer CAPS Protéines) (LRP5) gain-of-function mutations do not activate beta-catenin (Montrer CTNNB1 Protéines) signaling in osteoblasts.

  8. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST (Montrer SOST Protéines) and DKK1 (Montrer DKK1 Protéines).

  9. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models.

  10. In hypercholesterolemia LRP5(-/-) mice Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathway was shut down. An antiatherogenic role for LRP5 was demonstrated as HC LRP5(-/-) mice developed larger aortic atherosclerotic lesions than WT mice.

Profil protéine LRP5

Profil protéine

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Alternative names and synonyms associated with LRP5

  • low density lipoprotein receptor-related protein 5 (LRP5)
  • low density lipoprotein receptor-related protein 5 (lrp5)
  • low density lipoprotein receptor-related protein 5 (LOC100220027)
  • low density lipoprotein receptor-related protein 5 (Lrp5)
  • BMND1 Protéine
  • EVR1 Protéine
  • EVR4 Protéine
  • HBM Protéine
  • LR3 Protéine
  • LRP5 Protéine
  • lrp5-A Protéine
  • LRP6 Protéine
  • LRP7 Protéine
  • mKIAA4142 Protéine
  • OPPG Protéine
  • OPS Protéine
  • OPTA1 Protéine
  • VBCH2 Protéine
  • Xlrp5 Protéine

Protein level used designations for LRP5

Lipoprotein Receptor Related Protein 5 , low density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5-like , LRP-5 , low density lipoprotein receptor-related protein 7 , LRP-7 , low-density lipoprotein receptor-related protein 7

GENE ID SPECIES
100147353 Equus caballus
100009566 Oryctolagus cuniculus
373722 Xenopus laevis
451380 Pan troglodytes
568518 Danio rerio
100189542 Papio anubis
100220027 Taeniopygia guttata
100406268 Callithrix jacchus
100473379 Ailuropoda melanoleuca
100491803 Xenopus (Silurana) tropicalis
100548748 Meleagris gallopavo
4041 Homo sapiens
16973 Mus musculus
293649 Rattus norvegicus
423114 Gallus gallus
100306933 Canis lupus familiaris
534450 Bos taurus
100524299 Sus scrofa
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