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anti-Human TCF7 Anticorps:
anti-Rat (Rattus) TCF7 Anticorps:
anti-Mouse (Murine) TCF7 Anticorps:
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Human Polyclonal TCF7 Primary Antibody pour EIA, WB - ABIN357291
Smit, Baas, Kuipers, Korswagen, van de Wetering, Clevers: Wnt activates the Tak1/Nemo-like kinase pathway. dans The Journal of biological chemistry 2004
Show all 5 references for ABIN357291
Human Polyclonal TCF7 Primary Antibody pour ELISA, WB - ABIN1533714
Roose, Huls, van Beest, Moerer, van der Horn, Goldschmeding, Logtenberg, Clevers: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. dans Science (New York, N.Y.) 1999
Human Polyclonal TCF7 Primary Antibody pour WB - ABIN2777292
Willinger, Freeman, Herbert, Hasegawa, McMichael, Callan: Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. dans Journal of immunology (Baltimore, Md. : 1950) 2006
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (Montrer MLLT11 Anticorps)/TCF7/CD44 (Montrer CD44 Anticorps) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (Montrer GIP Anticorps)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (Montrer CTNNB1 Anticorps) signaling due to the dissociation of beta-catenin (Montrer CTNNB1 Anticorps)/TCF-1 (Montrer HNF1A Anticorps) complex and the process was orchestrated by STAT-3 (Montrer STAT3 Anticorps).
we show that TCF7 is a direct target of miR (Montrer MLXIP Anticorps)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (Montrer WNT2 Anticorps) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (Montrer RUNX2 Anticorps) signaling pathways with their partners TCF7 and FGFR1 (Montrer FGFR1 Anticorps)/2 may not be involved in CCD (Montrer RUNX2 Anticorps) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (Montrer HNF4A Anticorps) transcription factor pathway response blocker to treat WNT (Montrer WNT2 Anticorps)-TCF (Montrer HNF4A Anticorps)-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT (Montrer TERT Anticorps) and the TCF7 transcription factor, which mediates the canonical Wnt (Montrer WNT2 Anticorps) pathway.
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (Montrer GIP Anticorps) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (Montrer MLXIP Anticorps)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (Montrer HNF1A Anticorps) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (Montrer MLXIP Anticorps)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (Montrer HNF1A Anticorps) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (Montrer HNF1A Anticorps) promoted Bcl-6 (Montrer BCL6 Anticorps) expression but repressed Blimp1 (Montrer PRDM1 Anticorps) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor (Montrer CCR1 Anticorps) Ccr7 (Montrer CCR7 Anticorps) as Foxo1 (Montrer FOXO1 Anticorps)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function.
TCF-1 (Montrer HNF1A Anticorps) mediates repression of Notch (Montrer NOTCH1 Anticorps) pathway in T lineage-committed early thymocytes.
These results are reminiscent of the critical roles of TCF-1 (Montrer HNF1A Anticorps) in early T cell development.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1