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High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (Montrer MLLT11 Kits ELISA)/TCF7/CD44 (Montrer CD44 Kits ELISA) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (Montrer GIP Kits ELISA)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (Montrer CTNNB1 Kits ELISA) signaling due to the dissociation of beta-catenin (Montrer CTNNB1 Kits ELISA)/TCF-1 (Montrer HNF1A Kits ELISA) complex and the process was orchestrated by STAT-3 (Montrer STAT3 Kits ELISA).
we show that TCF7 is a direct target of miR (Montrer MLXIP Kits ELISA)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (Montrer WNT2 Kits ELISA) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (Montrer RUNX2 Kits ELISA) signaling pathways with their partners TCF7 and FGFR1 (Montrer FGFR1 Kits ELISA)/2 may not be involved in CCD (Montrer RUNX2 Kits ELISA) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (Montrer HNF4A Kits ELISA) transcription factor pathway response blocker to treat WNT (Montrer WNT2 Kits ELISA)-TCF (Montrer HNF4A Kits ELISA)-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT (Montrer TERT Kits ELISA) and the TCF7 transcription factor, which mediates the canonical Wnt (Montrer WNT2 Kits ELISA) pathway.
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (Montrer GIP Kits ELISA) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (Montrer MLXIP Kits ELISA)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (Montrer HNF1A Kits ELISA) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (Montrer MLXIP Kits ELISA)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (Montrer HNF1A Kits ELISA) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (Montrer HNF1A Kits ELISA) promoted Bcl-6 (Montrer BCL6 Kits ELISA) expression but repressed Blimp1 (Montrer PRDM1 Kits ELISA) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor (Montrer CCR1 Kits ELISA) Ccr7 (Montrer CCR7 Kits ELISA) as Foxo1 (Montrer FOXO1 Kits ELISA)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function.
TCF-1 (Montrer HNF1A Kits ELISA) mediates repression of Notch (Montrer NOTCH1 Kits ELISA) pathway in T lineage-committed early thymocytes.
These results are reminiscent of the critical roles of TCF-1 (Montrer HNF1A Kits ELISA) in early T cell development.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1