anti-Humain EPOR anticorps pour Cell-ELISA

Recommended EPOR Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Erythropoietin Receptor (EPOR) Anticorps
  • EPOR
  • epor
  • EPO-R
  • erythropoietin receptor
  • Erythropoietin receptor
  • erythropoietin receptor homologue
  • erythropoietin receptor-like
  • EPOR
  • epor
  • Epor
  • LOC100355350
Reactivité
Humain
196
80
73
7
4
3
3
2
2
2
1
1
1
Hôte
Souris
142
54
13
1
Clonalité
Monoclonal
Conjugué
Cet anticorp EPOR est non-conjugé
13
9
8
6
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Cell-ELISA (cELISA), Flow Cytometry (FACS)
158
82
53
49
35
34
32
16
13
7
5
2
2
2
1
1
1
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N° du produit ABIN1720915
330,00 €
Plus frais de livraison 40,00 € et TVA

anti-EPOR anticorps pour Cell-ELISA mieux référencés

anti-EPOR Anticorps

Application / Reactivité Humain
Cell Culture (CC) 1 Anticorps
Cell-ELISA (cELISA) 1 Anticorps
ELISA 70 Anticorps
ELISA (Detection) 1 Anticorps
Enzyme Immunoassay (EIA) 5 Anticorps
Flow Cytometry (FACS) 35 Anticorps
Immunochromatography (IC) 2 Anticorps
Immunocytochemistry (ICC) 30 Anticorps
Immunofluorescence (IF) 49 Anticorps
Immunofluorescence (fixed cells) (IF/ICC) 5 Anticorps
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Anticorps
Immunohistochemistry (IHC) 47 Anticorps
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 35 Anticorps
Immunoprecipitation (IP) 14 Anticorps
Neutralization (Neut) 1 Anticorps
Radioimmunoassay (RIA) 2 Anticorps

General

Antigène Erythropoietin Receptor (EPOR) Anticorps
Reactivité Humain
(196), (80), (73), (7), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Hôte Souris
(142), (54), (13), (1)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp EPOR est non-conjugé
(13), (9), (8), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Cell-ELISA (cELISA), Flow Cytometry (FACS)
(158), (82), (53), (49), (35), (34), (32), (16), (13), (7), (5), (2), (2), (2), (1), (1), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-EPOR anticorps

Détail du antigène EPOR Information d'application Stockage ProductDetails: References for anti-EPOR antibody (ABIN1720915) Images
Specificité Anti-human Epo-R
Attributs du produit Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells
Purification Protein G
Immunogène genetic immunisation with cDNA encoding the ECD of human Epo-R
Clone VP-2E8
Isotype IgG1

Détail du antigène EPOR

Détail du produit anti-EPOR anticorps Information d'application Stockage ProductDetails: References for anti-EPOR antibody (ABIN1720915) Images Haut de la page
Antigène
Autre désignation EPOR (EPOR Antibody Extrait)
Sujet Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo). Erythropoietin is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the Epo receptor. The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance.
UniProt P19235
Pathways Signalistation JAK/STAT

Information d'application

Détail du produit anti-EPOR anticorps Détail du antigène EPOR Stockage ProductDetails: References for anti-EPOR antibody (ABIN1720915) Images Haut de la page
Indications d'application Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.
Commentaires

Synonyms: Erythropoietin receptor

Restrictions For Research Use only

Stockage

Détail du produit anti-EPOR anticorps Détail du antigène EPOR Information d'application ProductDetails: References for anti-EPOR antibody (ABIN1720915) Images Haut de la page
Buffer PBS, pH 7.2
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C
Stockage commentaire short term: 2 °C - 8 °C, long term: -20 °C

ProductDetails: References for anti-EPOR antibody (ABIN1720915)

Détail du produit anti-EPOR anticorps Détail du antigène EPOR Information d'application Stockage Images Haut de la page
Produit citée dans:

Maxwell, Melendez-Rodríguez, Matchett, Aragones, Ben-Califa, Jaekel, Hengst, Lindner, Bernardini, Brockmeier, Fandrey, Grunert, Oster, Mittelman, El-Tanani, Thiersch, Schneider Gasser, Gassmann et al.: "Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. ..." dans: British journal of haematology, Vol. 168, Issue 3, pp. 429-42, 2015

Hedley, Allan, Xenocostas: "The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 20, pp. 6373-80, 2011

Background publications

Wilson, Jolliffe: "The structure, organization, activation and plasticity of the erythropoietin receptor." dans: Current opinion in structural biology, Vol. 9, Issue 6, pp. 696-704, 2000

Livnah, Stura, Middleton, Johnson, Jolliffe, Wilson: "Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation." dans: Science (New York, N.Y.), Vol. 283, Issue 5404, pp. 987-90, 1999

Winkelmann: "The human erythropoietin receptor." dans: International journal of cell cloning, Vol. 10, Issue 5, pp. 254-61, 1993

Images

Détail du produit anti-EPOR anticorps Détail du antigène EPOR Information d'application Stockage ProductDetails: References for anti-EPOR antibody (ABIN1720915) Haut de la page
Supplier Images
Flow Cytometry (FACS) image for anti-EPOR anticorps (Erythropoietin Receptor) (ABIN1720915) BOSC23 cells were transiently transfected with an expression vector encoding either E...
SDS-PAGE (SDS) image for anti-EPOR anticorps (Erythropoietin Receptor) (ABIN1720915) CGE analysis of purified VP-2E8 monoclonal antibody. Lane 1: molecular weight marker,...
Western Blotting (WB) image for anti-EPOR anticorps (Erythropoietin Receptor) (ABIN1720915) Immunoprecipitation of EpoR with and from A549 lung carcinoma cells expressing contro...