anti-Humain IL2RG anticorps pour Immunohistochemistry (Paraffin-embedded Sections)

Recommended IL2RG Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 2 Receptor, gamma (IL2RG) Anticorps
  • Ab2-183
  • Cd132
  • CD132
  • CIDX
  • IL-2RG
  • IMD4
  • P64
  • SCIDX
  • SCIDX1
  • [g]c
  • gamma(c)
  • gc
  • interleukin 2 receptor, gamma
  • interleukin 2 receptor, gamma chain
  • IL2RG
  • il2rg
  • Il2rg
Épitope
AA 135-185
34
16
15
15
14
10
8
8
7
5
5
4
4
4
3
3
2
2
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
145
95
29
2
1
Hôte
Lapin
90
58
51
4
Clonalité
Polyclonal
Conjugué
Cet anticorp IL2RG est non-conjugé
12
10
10
9
9
9
9
9
8
8
5
4
4
3
3
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
114
73
47
15
12
10
9
3
3
3
2
2
1
1
1
1
1
Options
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N° du produit ABIN2176981
$ 295.90
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN2176992 IHC (p) WB HRP Rabbit IgG AA 135-185 Connectez-vous pour afficher Polyclonal
1 ABIN2176986 IHC (p) WB Biotin Rabbit IgG AA 135-185 Connectez-vous pour afficher Polyclonal

General

Antigène Interleukin 2 Receptor, gamma (IL2RG) Anticorps
Épitope AA 135-185
(34), (16), (15), (15), (14), (10), (8), (8), (7), (5), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(145), (95), (29), (2), (1)
Hôte Lapin
(90), (58), (51), (4)
Clonalité
Polyclonal
Conjugué Cet anticorp IL2RG est non-conjugé
(12), (10), (10), (9), (9), (9), (9), (9), (8), (8), (5), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(114), (73), (47), (15), (12), (10), (9), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL2RG anticorps

Détail du antigène IL2RG Information d'application Stockage Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from human IL-2R gamma
Isotype IgG

Détail du antigène IL2RG

Détail du produit anti-IL2RG anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation Il-2r gamma (IL2RG Antibody Extrait)
Sujet

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.

Subcellular location: Extracellular

Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG

ID gène 3561
UniProt P31785
Pathways Signalistation JAK/STAT, Growth Factor Binding

Information d'application

Détail du produit anti-IL2RG anticorps Détail du antigène IL2RG Stockage Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-IL2RG anticorps Détail du antigène IL2RG Information d'application Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

Images

Détail du produit anti-IL2RG anticorps Détail du antigène IL2RG Information d'application Stockage Haut de la page
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Immunofluorescence (IF) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin-embedded human lung labeled with Anti-IL-2R gamma Polyclo...
Western Blotting (WB) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) L1 rat spleen lysates L2 mouse heart lysates probed with Anti IL-2R gamma/CD132 Polyc...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Flow Cytometry (FACS) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Human U937 cells probed with IL-2R gamma Polyclonal Antibody, Unconjugated (green) a...