anti-Grenouille JAK1 anticorps pour Immunofluorescence

Recommended JAK1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Janus Kinase 1 (JAK1) Anticorps
  • JNK
  • JNK1
  • JAK1
  • jak1
  • JAK1A
  • JAK1B
  • JTK3
  • AA960307
  • C130039L05Rik
  • wu:fb93e10
  • Janus kinase 1
  • mitogen-activated protein kinase 8
  • Tyrosine-protein kinase Jak1
  • JAK1
  • MAPK8
  • jak1
  • Jak1
Épitope
AA 551-766
29
19
16
15
15
10
7
7
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Poulet, Chien, Grenouille, Humain, Souris, Rat (Rattus)
124
101
84
5
5
4
4
1
Hôte
Souris
112
16
9
1
Clonalité
Monoclonal
Conjugué
Cet anticorp JAK1 est non-conjugé
4
4
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
85
59
48
17
13
13
9
9
5
4
2
1
Options
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N° du produit ABIN967842
265,69 €
Plus frais de livraison 40,00 € et TVA
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
12.3212185 ABIN967841 IF IP IHC WB Mouse IgG1, kappa AA 551-766 Connectez-vous pour afficher 73-JAK1 5

anti-JAK1 anticorps pour Immunofluorescence mieux référencés

  • Chicken Monoclonal JAK1 Primary Antibody pour IF, IP - ABIN967842 (5 Publications): Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. dans Oncogene 2001 (PubMed)

  • Chicken Monoclonal JAK1 Primary Antibody pour IF, IP - ABIN967841 (5 Publications): Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. dans The Journal of experimental medicine 2001 (PubMed)

anti-JAK1 Anticorps

Application / Reactivité Humain Souris Rat (Rattus) Poulet Chien Grenouille
Immunofluorescence (fixed cells) (IF/ICC) 3 Anticorps 3 Anticorps 2 Anticorps 1 Anticorps 1 Anticorps
Western Blotting (WB) 74 Anticorps 60 Anticorps 46 Anticorps 5 Anticorps 5 Anticorps 2 Anticorps
Immunoprecipitation (IP) 9 Anticorps 2 Anticorps 2 Anticorps 2 Anticorps 6 Anticorps 5 Anticorps
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Anticorps 11 Anticorps 9 Anticorps

General

Antigène Janus Kinase 1 (JAK1) Anticorps
Épitope AA 551-766
(29), (19), (16), (15), (15), (10), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Poulet, Chien, Grenouille, Humain, Souris, Rat (Rattus)
(124), (101), (84), (5), (5), (4), (4), (1)
Hôte Souris
(112), (16), (9), (1)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp JAK1 est non-conjugé
(4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(85), (59), (48), (17), (13), (13), (9), (9), (5), (4), (2), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-JAK1 anticorps

Détail du antigène JAK1 Information d'application Stockage ProductDetails: References for anti-JAK1 antibody (ABIN967842) Images
 Réactivité croisée Chien, Rat (Rattus), Souris, Poulet, Grenouille
Attributs du produit 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogène Human JAK1 aa. 551-766
Clone 73-JAK1
Isotype IgG1, kappa

Détail du antigène JAK1

Détail du produit anti-JAK1 anticorps Information d'application Stockage ProductDetails: References for anti-JAK1 antibody (ABIN967842) Images Haut de la page
Antigène
Autre désignation JAK1 (JAK1 Antibody Extrait)
Sujet The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.
Poids moléculaire 130 kDa
Domaine de recherche Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades

Information d'application

Détail du produit anti-JAK1 anticorps Détail du antigène JAK1 Stockage ProductDetails: References for anti-JAK1 antibody (ABIN967842) Images Haut de la page
Commentaires

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Stockage

Détail du produit anti-JAK1 anticorps Détail du antigène JAK1 Information d'application ProductDetails: References for anti-JAK1 antibody (ABIN967842) Images Haut de la page
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store undiluted at -20°C.

ProductDetails: References for anti-JAK1 antibody (ABIN967842)

Détail du produit anti-JAK1 anticorps Détail du antigène JAK1 Information d'application Stockage Images Haut de la page
Produit citée dans:

Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." dans: Oncogene, Vol. 21, Issue 44, pp. 6791-800, 2002

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." dans: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001

Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." dans: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, 2001

Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." dans: Nature, Vol. 366, Issue 6451, pp. 129-35, 1993

Background publications

Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2985-8, 1994

Images

Détail du produit anti-JAK1 anticorps Détail du antigène JAK1 Information d'application Stockage ProductDetails: References for anti-JAK1 antibody (ABIN967842) Haut de la page
Supplier Images
Western Blotting (WB) image for anti-JAK1 anticorps (Janus Kinase 1) (AA 551-766) (ABIN967842) Western blot analysis of JAK1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, la...
Immunofluorescence (IF) image for anti-JAK1 anticorps (Janus Kinase 1) (AA 551-766) (ABIN967842) Immunofluorescent staining of Human Endothelial cells.
 image for anti-JAK1 anticorps (Janus Kinase 1) (AA 551-766) (ABIN967842) anti-Janus Kinase 1 (JAK1) (AA 551-766) antibody (Image 3)