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Rat (Rattus) JAK2 Kit ELISA pour Sandwich ELISA - ABIN435372
Li, Ma, Jiang, Bai, Yan, Liu, Pan, Liu, Chen: Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus. dans Scientific reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (Montrer IFNG Kits ELISA) signal.
JAK2(V617F) mutation is associated with myelofibrosis.
the frequencies of mutations from JAK2 wild-type to JAK2V617F and vice versa increased following erythroid differentiation
we report that the recipient and the donor JAK2 46/1 haplotypes are significantly associated with aGvHD grades II-IV in AML (Montrer RUNX1 Kits ELISA) patients undergoing allo-HSCT.
our studies suggest that the JAK2(V617F)-bearing ECs form an important component of the myeloproliferative neoplasms vascular niche and contribute to mutant stem/progenitor cell expansion, likely through a critical role of the TPO (Montrer THPO Kits ELISA)/MPL (Montrer MPL Kits ELISA) signaling axis.
Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).
dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl (Montrer ABL1 Kits ELISA), STAT5 (Montrer STAT5A Kits ELISA), JAK2, and STAT3 (Montrer STAT3 Kits ELISA) and downstream molecules including p-CrkL (Montrer CRKL Kits ELISA), Mcl-1 (Montrer MCL1 Kits ELISA), Bcl-XL (Montrer BCL2L1 Kits ELISA), and Bcl-2 (Montrer BCL2 Kits ELISA) proteins in K562 cells.
JAK2V617F mutation influences myeloproliferative neoplasm-associated inflammation with a strong correlation between allele burden and PTX3 (Montrer PITX3 Kits ELISA) levels.
TGR5 (Montrer GPBAR1 Kits ELISA) exhibits significantly higher expression in NSCLC tumor samples and facilitates the growth and metastasis of NSCLC by activating the JAK2/STAT3 (Montrer STAT3 Kits ELISA) signaling pathway.
JAK2V617F mutations were found in 59 patients in the olycythemia vera (Montrer IGF2BP3 Kits ELISA) group
Essential Thrombocythemia and Primary Myelofibrosis patients with JAK2 V617F mutations are at high risk for Thrombotic Events.
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (Montrer STAT3 Kits ELISA) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (Montrer STAT3 Kits ELISA) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (Montrer CISH Kits ELISA) interacted with phosphorylated EpoR (Montrer EPOR Kits ELISA) at Y401, which was critical for the activation of STAT5 (Montrer STAT5A Kits ELISA) and ERK (Montrer EPHB2 Kits ELISA).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (Montrer CBL Kits ELISA)(mut (Montrer MUT Kits ELISA)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (Montrer EZH2 Kits ELISA) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (Montrer EZH2 Kits ELISA) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (Montrer EZH2 Kits ELISA)
findings demonstrate that clinically relevant doses of the JAK1 (Montrer JAK1 Kits ELISA)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (Montrer JAK3 Kits ELISA)-STAT (Montrer STAT1 Kits ELISA)-AKT (Montrer AKT1 Kits ELISA) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (Montrer STAT5A Kits ELISA) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (Montrer STAT5A Kits ELISA) and mTOR (Montrer FRAP1 Kits ELISA) signaling pathways.
SNPs in JAK2 and STAT5B (Montrer STAT5B Kits ELISA) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase