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Rat (Rattus) JAK2 Kit ELISA pour Sandwich ELISA - ABIN435372
Li, Ma, Jiang, Bai, Yan, Liu, Pan, Liu, Chen: Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus. dans Scientific reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (Montrer IFNG Kits ELISA) signal.
Testing for JAK2 mutations is now included in the World Health Organization (WHO) criteria for the diagnosis of MPN (Montrer PRSS27 Kits ELISA), and in 2011 the oral JAK2 kinase inhibitor ruxolitinib became the first Food and Drug Administration (FDA (Montrer FDA Kits ELISA))-approved drug for the treatment of myelofibrosis.
In our study, there was no genotypic or phenotypic association between the JAK2 rs10758669 variant and UC. Only the (C) allele was identified to increase the risk of a more severe disease progression.
C-CALR (Montrer CALR Kits ELISA) in response to Ca2 (Montrer CA2 Kits ELISA)+ undergoes conformational changes that trigger its function to export GR from the nucleus, resetting the stress response of normal erythroid cells. Impairment of this function in JAK2V617F-positive erythroid cells maintains EPO-R (Montrer EPOR Kits ELISA) signaling in proliferation mode, contributing to erythrocytosis in PV.
BRM (Montrer SMARCA2 Kits ELISA) could activate JAK2/STAT3 (Montrer STAT3 Kits ELISA) pathway to promote pancreatic cancer growth and chemoresistance.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
Multiple myeloma cells over express JAK1 (Montrer JAK1 Kits ELISA)/2 and suggest combined chemotherapy with ruxolitinib, bortezomib and lenalidomide to inhibit JAK (Montrer JAK3 Kits ELISA)/STAT (Montrer STAT1 Kits ELISA) pathway.
Molecular interactions of EphA4 (Montrer EPHA4 Kits ELISA), growth hormone receptor (Montrer GHR Kits ELISA), Jak2, and STAT5B (Montrer STAT5B Kits ELISA) have been described.
Peritoneal membrane dysfunction in long-term peritoneal dialysis patients may result from IL-6 (Montrer IL6 Kits ELISA) promotion of epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 (Montrer STAT3 Kits ELISA) signaling pathway.
Mutation inactivating JAK2 gene is associated with Breast Cancer Metastasis.
mechanical load upregulates expression of Runx2 (Montrer RUNX2 Kits ELISA) gene via potentiation of PC1 (Montrer PCSK1 Kits ELISA)-JAK2/STAT3 (Montrer STAT3 Kits ELISA) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (Montrer CBL Kits ELISA)(mut (Montrer MUT Kits ELISA)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (Montrer EZH2 Kits ELISA) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (Montrer EZH2 Kits ELISA) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (Montrer EZH2 Kits ELISA)
findings demonstrate that clinically relevant doses of the JAK1 (Montrer JAK1 Kits ELISA)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways
Data show that CUZD1 (Montrer CUZD1 Kits ELISA) interacts with a complex containing JAK1 (Montrer JAK1 Kits ELISA)/JAK2 and STAT5 (Montrer STAT5A Kits ELISA), downstream transducers of prolactin (Montrer PRL Kits ELISA) signaling in the mammary gland.
The results showed that AG490 inhibited (p)-JAK2 and RANKL (Montrer TNFSF11 Kits ELISA) expression.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (Montrer JAK3 Kits ELISA)-STAT (Montrer STAT1 Kits ELISA)-AKT (Montrer AKT1 Kits ELISA) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (Montrer STAT5A Kits ELISA) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (Montrer STAT5A Kits ELISA) and mTOR (Montrer FRAP1 Kits ELISA) signaling pathways.
SNPs in JAK2 and STAT5B (Montrer STAT5B Kits ELISA) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase