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anti-Mouse (Murine) PIAS1 Anticorps:
anti-Human PIAS1 Anticorps:
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Human Polyclonal PIAS1 Primary Antibody pour IHC (p), WB - ABIN388054
Miyauchi, Yogosawa, Honda, Nishida, Yasuda: Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. dans The Journal of biological chemistry 2002
Show all 7 Pubmed References
these results indicate that PIAS1 is a positive regulator of MYC (Montrer MYC Anticorps).
PIAS1 overexpression exacerbated mutant Huntingtin-associated (Montrer KALRN Anticorps) phenotypes and aberrant protein accumulation
Pias1 expression in primary myoblasts enhances the induction of cardiac muscle genes MyoD (Montrer MYOD1 Anticorps), Myogenin (Montrer MYOG Anticorps) and Myomaker. Endothelial cell specific inactivation of Pias1 in vivo impairs yolk sac (Montrer ADCY10 Anticorps) erythrogenesis, angiogenesis and recapitulates loss of myocardium muscle mass. Pias1 is an essential gene for YS erythropoiesis and vasculogenesis in vivo.
Data suggest overexpression of Pias1 in white adipose tissue (WAT) of obesity/prediabetes improves insulin (Montrer INS Anticorps) resistance; knockdown of Pias1 in normal WAT leads to insulin (Montrer INS Anticorps) resistance; Pias1 expression in WAT is down-regulated by c-Jun N-terminal kinase.
Between the E3 SUMO ligase PIAS1 and STAT-3 (Montrer STAT3 Anticorps).
Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 (Montrer STIP1 Anticorps) in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 (Montrer STIP1 Anticorps) binding site is unable to increase STI1 (Montrer STIP1 Anticorps) nuclear retention.
A novel role of PIAS1 in maintaining the quiescence of dormant hematopoietic stem cells and in the epigenetic repression of the myeloerythroid program.
The present study showed that PIAS1 functions as a SUMO E3 ligase of C/EBPbeta (Montrer CEBPB Anticorps) to regulate adipogenesis.
Piasy (Montrer PIAS4 Anticorps) represses the synergistic activation of PITX2 (Montrer PITX2 Anticorps) with interacting co-factors and Piasy (Montrer PIAS4 Anticorps) represses Pias1 activation of PITX2 (Montrer PITX2 Anticorps) transcriptional activity.
MAPK-activated protein kinase-2 limits endothelial inflammation via the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity.
PIAS1 is a prognostic biomarker in breast cancer
PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
HBs protein-induced hPIAS1 transcription requires TAL1 (Montrer TAL1 Anticorps), E47 (Montrer TCF3 Anticorps), MYOG (Montrer MYOG Anticorps), NFI (Montrer NFIC Anticorps), and MAPK (Montrer MAPK1 Anticorps) signal pathways
identified the SUMO ligase PIAS1 as a constituent PML (Montrer PML Anticorps)-NB antiviral protein. This finding distinguishes a SUMO ligase that may mediate signaling events important in promyelocytic leukemia (Montrer PML Anticorps) nuclear body mediated intrinsic immunity.
PIAS1 enhances p300 (Montrer EP300 Anticorps) recruitment to c-Myb (Montrer MYB Anticorps)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation
Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.
c-Myc (Montrer MYC Anticorps) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 (Montrer SENP7 Anticorps) and RNF4 (Montrer RNF4 Anticorps)
Data demonstrate that PIAS1 interacts with TRF2 (Montrer TERF2 Anticorps) and mediates its sumoylation serving as a molecular switch that controls the level of TRF2 (Montrer TERF2 Anticorps) at telomeres.
This gene encodes a member of the mammalian PIAS
protein inhibitor of activated STAT, 1
, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
, DEAD/H box-binding protein 1
, E3 SUMO-protein ligase PIAS1
, protein inhibitor of activated STAT protein 1
, AR interacting protein
, RNA helicase II-binding protein
, gu-binding protein
, protein inhibitor of activated STAT-1
, zinc finger, MIZ-type containing 3
, SUMO E3 ligase