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The TBK1 (Montrer TBK1 Kits ELISA) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (Montrer TBK1 Kits ELISA).
identified both Syk (Montrer SYK Kits ELISA) and Src signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
results indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB (Montrer NCAPG2 Kits ELISA) infection
c-Src tyrosine kinase (Montrer CSK Kits ELISA) mediates high glucose-induced endothelin-1 (Montrer EDN1 Kits ELISA) expression
PTPN2 (Montrer PTPN2 Kits ELISA) is a positive regulator of lipopolysaccharide-induced inflammatory response by enhancing the activity of Src through targeting the inhibitory phosphor-tyrosine527 of Src.
demonstrated that both IL-10 (Montrer IL10 Kits ELISA) and TGF-beta (Montrer TGFB1 Kits ELISA) upregulated TIM-3 (Montrer HAVCR2 Kits ELISA) surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src and Bruton's tyrosine kinase (Montrer BTK Kits ELISA)
Results suggest that interleukin-6 (IL-6 (Montrer IL6 Kits ELISA)) increases VEGF-C (Montrer VEGFC Kits ELISA) induction and lymphangiogenesis may involve, at least in part, Src-FAK (Montrer PTK2 Kits ELISA)-STAT3 (Montrer STAT3 Kits ELISA) cascade in lymphatic endothelial cells (LECs).
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line has been reported.
Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.
miR (Montrer MLXIP Kits ELISA)-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K (Montrer CTSK Kits ELISA) and TRAP.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (Montrer TMOD4 Kits ELISA) (CP) alphabeta heterodimer, which regulates actin (Montrer ACTB Kits ELISA) filament (F-actin (Montrer ACTB Kits ELISA)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (Montrer MAPK8 Kits ELISA) activation.
Dumbfounded/Neph1 (Montrer NEPH1 Kits ELISA), a key diaphragm constituent, is a target of the Src kinase (Montrer CSK Kits ELISA) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (Montrer NEPH1 Kits ELISA) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (Montrer ACTB Kits ELISA) formation and Jun kinase (Montrer MAPK9 Kits ELISA) activation in plasmatocytes.
Data show that the solubilising factor UNC119 (Montrer UNC119 Kits ELISA) sequesters myristoylated Src family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction.
Data indicate a role for AXL receptor tyrosine kinase (AXL (Montrer AXL Kits ELISA)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (Montrer EGFR Kits ELISA)) and suggest that AXL (Montrer AXL Kits ELISA)-mediated SRC family kinases (SFKs) and neuregulin-1 (NRG1 (Montrer NRG1 Kits ELISA)) expression promote this process.
High Src expression is associated with breast cancer.
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (Montrer GRK5 Kits ELISA) and GRK6 (Montrer GRK6 Kits ELISA), both of which regulate Src and IGF-IR signaling and have been implicated in cancer.
Src knockdown in Cal27 cells which led to a reduction in pSrc(Y418), as well as treatment with the pSrc(Y418) inhibitors dasatinib and PP2, conferred resistance to 4 anticancer drugs, indicating that the loss of pSrc(Y418) is responsible for the observed effect.
High SRC expression is associated with ovarian cancer.
RanBP9 (Montrer RANBP9 Kits ELISA)/TSSC3 (Montrer PHLDA2 Kits ELISA) complex cooperatively suppress metastasis via downregulation of Src-dependent Akt (Montrer AKT1 Kits ELISA) pathway to expedite mitochondrial-associated anoikis.
In addition, EB1 (Montrer MAPRE2 Kits ELISA) phosphorylation at Y247 by Src enhances the rate of microtubule catastrophe and significantly stimulates cell migration. These findings thus demonstrate that the Src-EB1 (Montrer MAPRE2 Kits ELISA) axis plays a crucial role in regulating the crosstalk between microtubules and focal adhesions to promote cell migration.
Results indicate Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL) in driving tumor metastasis through c-Src activation, and suggests that hSH3BGRL mutation status could be relevant to cancer diagnosis and therapy.
RhoA (Montrer RHOA Kits ELISA) and membrane fluidity mediates the spatially polarized Src/FAK (Montrer PTK2 Kits ELISA) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (Montrer TMPRSS5 Kits ELISA)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (Montrer TGFB1 Kits ELISA)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (Montrer PTK2 Kits ELISA)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (Montrer ATP1A1 Kits ELISA) activity and SFK signaling.
Src kinase (Montrer CSK Kits ELISA) mediates hypoxia-induced caspase-1 (Montrer CASP1 Kits ELISA) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (Montrer ATP1A1 Kits ELISA) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase