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anti-Mouse (Murine) STAT3 Anticorps:
anti-Human STAT3 Anticorps:
anti-Rat (Rattus) STAT3 Anticorps:
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Human Polyclonal STAT3 Primary Antibody pour IHC, WB - ABIN361960
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation. dans Toxicology 2006
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Human Polyclonal STAT3 Primary Antibody pour ICC, IHC (p) - ABIN3044335
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. dans Molecular medicine reports 2014
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN3043299
Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. dans BioMed research international 2013
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Human Polyclonal STAT3 Primary Antibody pour IF, IHC - ABIN361962
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... dans Cell biology international 2007
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN1881850
Li, Cheung, Evans, Shaw: Modulation of gene expression and tumor cell growth by redox modification of STAT3. dans Cancer research 2010
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Human Polyclonal STAT3 Primary Antibody pour IHC (p), WB - ABIN196690
Fan, Ballou, Lin: Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. dans The Journal of biological chemistry 2003
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Human Polyclonal STAT3 Primary Antibody pour IHC (p), WB - ABIN389665
Schick, Oakeley, Hynes, Badache: TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. dans The Journal of biological chemistry 2004
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Chicken Monoclonal STAT3 Primary Antibody pour IF, IP - ABIN967808
Buitenhuis, Baltus, Lammers, Coffer, Koenderman: Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. dans Blood 2002
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Chicken Monoclonal STAT3 Primary Antibody pour IF, IP - ABIN967809
Zhong, Wen, Darnell: Stat3 and Stat4: members of the family of signal transducers and activators of transcription. dans Proceedings of the National Academy of Sciences of the United States of America 1994
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Human Polyclonal STAT3 Primary Antibody pour FACS, IF (p) - ABIN732638
Yang, Sun, Sun, Qi: Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte. dans Molecular biology reports 2012
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Stat3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7 (Montrer PAX7 Anticorps).
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
this study shows that the upregulation of IL-10Ra (Montrer IL10RA Anticorps) by STAT3 contributed to the suppressive function of dendritic cellss following histone deacetylase (Montrer HDAC1 Anticorps) inhibition
APPL1 (Montrer APPL1 PLURAL_@2012@)-SirT1 (Montrer SIRT1 PLURAL_@2012@)-STAT3 pathway mediated adiponectin (Montrer ADIPOQ PLURAL_@2012@) signaling in primary hepatocytes.
HDL (Montrer HSD11B1 Anticorps)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin (Montrer BIRC5 Anticorps) expression.
loss of Fyn (Montrer FYN Anticorps) in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 phosphorylation
Results provide genetic evidence indicating that mTOR (Montrer FRAP1 Anticorps) and Raptor (Montrer RPTOR Anticorps) are required for sensory axon regeneration enhanced by peripheral lesions in mice, whereas Rictor (Montrer RICTOR Anticorps) plays a minor role. The peripheral lesion activates rapamycin-resistant mTOR (Montrer FRAP1 Anticorps) signaling to modulate Stat3 activity and further promotes axon regeneration.
These data describe a novel regulatory mechanism through which STAT3 and the Ikaros (Montrer IKZF1 Anticorps) zinc finger transcription factors Aiolos (Montrer IKZF3 Anticorps) and Ikaros (Montrer IKZF1 Anticorps) cooperate to regulate Bcl-6 (Montrer BCL6 Anticorps) expression.
Transplantation from GRIM19 (Montrer NDUFA13 Anticorps)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1 (Montrer NFATC1 Anticorps)) but promoted the expression of regulator of calcineurin (RCAN)3 (Montrer RCAN3 Anticorps) while downregulating NFAT (Montrer NFATC1 Anticorps)-dependent cytokine gene expression.
Data suggest MHV68 RTA (Montrer RBM9 Anticorps) specifically recognizes and recruits activated (phosphorylated at Tyr705) host Stat3 during lytic phase of infection; Stat3, once phosphorylated at Tyr705, avidly binds consensus target site in promoters of regulated genes. (MHV68 = murine gammaherpesvirus 68; RTA (Montrer RBM9 Anticorps) = replication and transcription activator coded for by ORF50; Stat3 = signal transducer and activator of transcription 3 protein)
High STAT3 expression is associated with recurrence in Glioma.
IL-27 (Montrer IL27 Anticorps) stimulation activated STAT1 (Montrer STAT1 Anticorps) and STAT3 in HeLa and T98G cells, suggesting that IL-27 (Montrer IL27 Anticorps) engages the STAT1 (Montrer STAT1 Anticorps)/3 pathway, which then leads to the upregulation of IL-6 (Montrer IL6 Anticorps), IP-10 (Montrer CXCL10 Anticorps), and MIG (Montrer CXCL9 Anticorps)
STAT3 and ATG12 (Montrer ATG12 Anticorps) are targets of miR (Montrer MLXIP Anticorps)-454-3p.
luteolin inhibited STAT3 activation through disrupting the binding of HSP-90 to STAT3, which promoted its interaction to SHP-1.
High STAT3 expression is associated with B-cell lymphoma.
PAI-1 (Montrer SERPINE1 Anticorps) was identified as the target gene of miR (Montrer MLXIP Anticorps)-34a and activated the Stat3 signaling pathway to promote epithelial-mesenchymal transition in non-small cell lung cancer cells.
These results suggest that miR146a may regulate SOCS1 (Montrer SOCS1 Anticorps)/STAT3 and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.
High STAT3 expression is associated with neuroblastoma (Montrer ARHGEF16 Anticorps).
simvastatin also increased p21 (Montrer CDKN1A Anticorps) and p27 (Montrer PAK2 Anticorps) expression in tumor sections by reducing Skp2 expression and inducing AMPK (Montrer PRKAA1 Anticorps) activation and STAT3 suppression in the same tumor tissues.
Overexpression of REP1 (Montrer CHM Anticorps) in BEAS-2B cells enhanced cell growth and anchorage-independent colony formation with little increase in EGFR (Montrer EGFR Anticorps) level and STAT3 activation.
STA3 (Montrer ARHGEF3 Anticorps) facilitates TLR4 (Montrer TLR4 Anticorps)-dependent IL-6 (Montrer IL6 Anticorps) and IL-8 (Montrer IL8 Anticorps) production via IL-6 (Montrer IL6 Anticorps) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (Montrer IL6 Anticorps) (IL), in the presence of its soluble receptor (Montrer IFNAR1 Anticorps) (sIL (Montrer STIL Anticorps)-6R), induces activation of JAK1 (Montrer JAK1 Anticorps), JAK2 (Montrer JAK2 Anticorps), and STAT1 (Montrer STAT1 Anticorps)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (Montrer VEGFA Anticorps) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (Montrer NOX1 Anticorps)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (Montrer CCND2 Anticorps) and PSEN1 (Montrer PSEN1 Anticorps) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (Montrer LIF Anticorps) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (Montrer FTH1 Anticorps)-supplemented media.
Data suggest that IL-6 (interleukin 6 (Montrer IL6 Anticorps)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (Montrer IL6 Anticorps)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (Montrer JAK1 Anticorps) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (Montrer MMP2 Anticorps) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (Montrer CDC25A Anticorps) expression during oogenesis. Accordingly, restoring Cdc25a (Montrer CDC25A Anticorps) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (Montrer PTPN9 Anticorps) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (Montrer GATA1 Anticorps) and ZBP-89 (Montrer ZNF148 Anticorps).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (Montrer SOCS3 Anticorps) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (Montrer RAB1A Anticorps) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (Montrer PRCP Anticorps) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3