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zili might have some effect on the formation of the ectoderm, mesoderm and endoderm during early embryogenesis
Tdrd1 binds both zebrafish Piwi (Montrer PIWIL1 Kits ELISA) proteins, Ziwi (Montrer PIWIL1 Kits ELISA) and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.
These results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish.
Zebrafish piwil2 is a mediator of Fgf signals in gastrula period.
data presented show that Zili suppresses TGF-beta (Montrer TGFB1 Kits ELISA) signaling by physically associating with Smad4 (Montrer SMAD4 Kits ELISA) and preventing the formation of Smad2 (Montrer SMAD2 Kits ELISA)/3/4 and Smad1 (Montrer SMAD1 Kits ELISA)/5/9/4 complexes
Ziwi (Montrer PIWIL1 Kits ELISA) and Zili bind piRNAs of opposite polarity
When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all PIWI-interacting RNA disappeared.
MILI is responsible for DNA methylation (Montrer HELLS Kits ELISA) of a larger subset of TE families than MIWI2 (Montrer PIWIL4 Kits ELISA).
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
Knockdown of MILI in B16 cell line could activate MAGEA expression and increase the cell migration ability, whereas the overexpression of MILI in B16BL6 cell line could inhibit MAGEA expression and decrease the cell migration ability.
Report shows that fly Aub, Bombyx mori Siwi, and mouse MILI select targets bearing a t1A (Montrer PDPN Kits ELISA) nucleotide irrespective of the identity of the g1 nucleotide of their piRNA guide.
Mice with a global deletion of all three piwi (Montrer PIWIL1 Kits ELISA) genes, Miwi (Montrer PIWIL1 Kits ELISA), Mili, and Miwi2 (Montrer PIWIL4 Kits ELISA), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
The in vitro studies show estrogen can downregulate the expression of miwi (Montrer PIWIL1 Kits ELISA) and mili.
characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1 (Montrer PIWIL1 Kits ELISA)), two Piwi (Montrer PIWIL1 Kits ELISA) proteins expressed in postnatal testis
a new role for Piwil2 in DNA repair
cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing
Data show that the PIWIL2 protein transfected fibroblast cells grew into tumorous masses within 5 weeks of subcutaneous injection into adult nude mice.
report demonstrated that human Piwil proteins, especially Hili, not only bind to select tRNA species, including rare tRNAs, but also inhibit HIV replication
PIWIL2 and PIWIL4 (Montrer PIWIL4 Kits ELISA) genes expression in synovial fibroblasts of the rheumatoid arthritis patients
MMP9 (Montrer MMP9 Kits ELISA) and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (Montrer CDK2 Kits ELISA) and Cyclin A (Montrer CCNA2 Kits ELISA) expression
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients
Univariate analysis demonstrated that high PIWIL2 expression was associated with shorter survival time after radical resection.
Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9 (Montrer MMP9 Kits ELISA)) compared to scrambled shRNA transfected cells
Results show that both PIWIL2 protein isoforms are expressed in testicular germ cell lines but in the tumors, the short protein and mRNA are predominant and highly expressed in undifferentiated tumors.
Our results indicate a reciprocal regulation between HIWI (Montrer PIWIL1 Kits ELISA), HILI and some CSCs markers in colorectal cancer
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
piwi-like protein 2
, piwi like 2
, Miwi like
, Miwi likw
, piwi like homolog 2
, piwi-like homolog 2
, cancer/testis antigen 80
, piwi-like 2
, piwil2-like protein