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Human Polyclonal PROX1 Primary Antibody pour IF, WB - ABIN1589859
Quagliata, Klusmeier, Cremers, Pytowski, Harvey, Pettis, Thiele, Sleeman: Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. dans Clinical & experimental metastasis 2014
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Human Polyclonal PROX1 Primary Antibody pour WB - ABIN1881686
Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. dans Genes, chromosomes & cancer 2003
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Human Monoclonal PROX1 Primary Antibody pour ICC, IF - ABIN2668929
Chen, Patel, Cain, Duncan: Production of monoclonal antibodies against Prox1. dans Hybridoma (2005) 2006
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Human Polyclonal PROX1 Primary Antibody pour ICC, IF - ABIN4347959
Abdolazimi, Stojanova, Segil: Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. dans Development (Cambridge, England) 2016
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Human Polyclonal PROX1 Primary Antibody pour IF, IHC (p) - ABIN929458
Kulkarni, Herman, Ikegami, Greenberg, Akeson: Lymphatic ontogeny and effect of hypoplasia in developing lung. dans Mechanisms of development 2011
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Chicken Monoclonal PROX1 Primary Antibody pour CyTOF, ELISA - ABIN447455
Sweat, Sloas, Murfee: VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model. dans Microcirculation (New York, N.Y. : 1994) 2014
In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
High PROX1 and beta-catenin (Montrer CTNNB1 Anticorps) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.
Data suggest that DBC1 (Montrer DBC1 Anticorps) has a dual function in regulating beta-catenin (Montrer CTNNB1 Anticorps)-PROX1 signaling axis: as a coactivator for both beta-catenin (Montrer CTNNB1 Anticorps) and PROX1.
PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (Montrer SLC12A2 Anticorps) rs17764730, PSMB5 (Montrer PSMB5 Anticorps) rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway.
High PROX1 expression is associated with gastric cancer.
High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.
Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells.
PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells.
Our study demonstrates that Prox1 (Montrer C16orf35 Anticorps)-GFP/Flk1 (Montrer KDR Anticorps)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Prox1 (Montrer C16orf35 Anticorps) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 (Montrer C16orf35 Anticorps) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (Montrer C16orf35 Anticorps) involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 (Montrer C16orf35 Anticorps) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
Prox1 (Montrer C16orf35 Anticorps) upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 (Montrer C16orf35 Anticorps) overexpression causes MafA (Montrer MAFA Anticorps) deficiency in beta-cells.
The PROX1 (Montrer C16orf35 Anticorps)-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis
suggest that Prox1 (Montrer C16orf35 Anticorps) appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality
we demonstrate that Prox1 (Montrer C16orf35 Anticorps) and Asap1 (Montrer ASAP1 Anticorps) behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
Prox1 (Montrer C16orf35 Anticorps) is made in postmitotic CGE-derived cortical interneuron precursors. It is differentially required during embryonic and postnatal stages for migration, differentiation, circuit integration, and maintenance programs in subtypes of these interneurons.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (Montrer OTOP1 Anticorps)-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1