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using an Mst2 (Montrer STK3 Kits ELISA) mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2 (Montrer STK3 Kits ELISA)-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH.
MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes.
Mst2 (Montrer STK3 Kits ELISA) and the Ser (Montrer SIGLEC1 Kits ELISA)-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45.
We also confirmed the interaction of HAX-1 (Montrer HAX1 Kits ELISA) and hSav1 in mammalian cells.
downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma.
MST (Montrer MAP3K10 Kits ELISA) and hSAV act as novel co-regulators of ERalpha (Montrer ESR1 Kits ELISA) and may play an important role in breast cancer pathogenesis.
hSav1 interacts with HAX1 (Montrer HAX1 Kits ELISA) and attenuates its protective role against apoptosis in MCF-7 breast cancer cells.
a role for Salvador as a human tumor suppressor and RASSF1A (Montrer RASSF1 Kits ELISA) effector and show that Salvador allows RASSF1A (Montrer RASSF1 Kits ELISA) to modulate p73 (Montrer TP73 Kits ELISA) independently of the hippo pathway.
Study reports that two Hippo pathway components, Mst2 and the scaffold protein hSav1, directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin.
hSav1 is a newly identified protein that interacts with Mst1 (Montrer MST1 Kits ELISA) and augments Mst1 (Montrer MST1 Kits ELISA)-mediated apoptosis.
Differentiation of 3T3-L1 cells was augmented by MST2 and SAV1 expression and inhibited by knockdown of MST1/2 or SAV1.
In this study, they investigated epigenetic characteristics of WW45+/- mice, evaluating time-dependent changes from prior to the onset of tumorigenesis to hepatocarcinoma.
show that mice with liver-specific ablation of WW45 (a homolog of Drosophila Salvador and adaptor for the Hippo kinase) manifest increased liver size and expansion of hepatic progenitor cells (oval cells) and eventually develop hepatomas.
show using a conditional allele of sav1, that an adaptor that potentiates mst1 (Montrer MST1 Kits ELISA) and mst2 (Montrer STK3 Kits ELISA) activity is likewise required to suppress growth in the mature liver and to prevent tumor formation.
While typical WW domains function as monomeric modules that recognize proline-rich sequences, by using conserved residues that are solvent-exposed on the surface of the beta-sheet, this WW domain (Montrer DRP2 Kits ELISA) buries these residues in the dimer interface.
Mice lacking WW45 reveal a crucial role for WW45 in cell-cycle exit and epithelial terminal differentiation.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
, 45 kDa WW domain protein
, WW domain-containing
, protein salvador homolog 1
, WW domain-containing protein 3
, WW domain-containing protein 4
, Salvador homolog 1 protein