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Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.
the Drosophila silver gene corresponds to a Carboxypeptidase D-like protein with three carboxypeptidase-like domains, a transmembrane domain, and a cytosolic tail
The molecular basis for the phenotype of 3 carboxypeptidase D mutations are presented.
Data show that Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions.
Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR (Montrer MLXIP Kits ELISA)-214
The human carboxypeptidase D transthyretin (Montrer TTR Kits ELISA)-like domain forms amyloid under physiological conditions.
Prolactin (Montrer PRL Kits ELISA) and R1881, acting through Stat5 (Montrer STAT5A Kits ELISA) and androgen receptor (Montrer AR Kits ELISA), act cooperatively to stimulate CPD gene transcription in breast cancer cells.
CPD immunostaining and testosterone/prolactin (Montrer PRL Kits ELISA)-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin (Montrer PRL Kits ELISA) receptors were inhibited.
Carboxypeptidase D (CPD) is frequently upregulated in hepatocellular carcinoma; targeting CPD inhibits hepatocellular carcinoma cell proliferation through induction of G1 cell-cycle arrest and apoptosis.
Either high glucose or insulin (Montrer INS Kits ELISA) (with low glucose) up-regulates beta-cell CPD (but not CPE (Montrer CPE Kits ELISA)).
Palmitoylation of carboxypeptidase D has a role in intracellular trafficking
The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
First report to demonstrate carboxypeptidase D as part of the transforming growth factor (TGF)-beta (Montrer TGFB1 Kits ELISA) pathway as a TGF-beta (Montrer TGFB1 Kits ELISA) target gene implicated in the pathogenesis of lupus erythematosus.
prolactin (Montrer PRL Kits ELISA) or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival
stress-alcohol locomotor cross-sensitization was regulated by Homer2 (Montrer HOMER2 Kits ELISA).
NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 (Montrer HOMER2 Kits ELISA) gene
mouse mutants homozygous for the targeted deletion of Homer2 (Montrer HOMER2 Kits ELISA) present with early-onset rapidly progressive hearing loss.
Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (Montrer ATP2B2 Kits ELISA) (PMCA) by Homer2 (Montrer HOMER2 Kits ELISA) protein that has a central role on PMCA-mediated Ca(2 (Montrer CA2 Kits ELISA)+) signaling in parotid acinar cells.
This study deministrated that PFC (Montrer CFP Kits ELISA) Homer2 (Montrer HOMER2 Kits ELISA) overexpression enhances cocaine-conditioned reward in mice.
Homer (Montrer HOMER1 Kits ELISA) 1b/c isoform is identical irrespective of the muscle; Homer (Montrer HOMER1 Kits ELISA) 2a/b is instead characteristic of the slow-twitch phenotype.
These data support the over-arching hypothesis that augmented accumbens Homer2 (Montrer HOMER2 Kits ELISA)-mediated glutamate (Montrer GRIN1 Kits ELISA) signaling may be an endophenotype related to genetic variance in alcohol consumption
Homer2 (Montrer HOMER2 Kits ELISA) tunes G protein-coupled receptors stimulus intensity by regulating RGS (Montrer PITX2 Kits ELISA) proteins and PLCbeta GAP activities.
In the developing olfactory bulb, Cupidin (Montrer HOMER2 Kits ELISA)/Homer (Montrer HOMER1 Kits ELISA) 2a/b is up-regulated in the granular, external plexiform, and glomerular layers
Homer2 (Montrer HOMER2 Kits ELISA) KO mice demonstrate enhanced locomotor stimulant and conditioned place preference responses to cocaine
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
, carboxypeptidase D
, carboxypeptidase E
, metallocarboxypeptidase D
, VASP/Ena-related gene up-regulated during seizure and LTP 2
, homer protein homolog 2
, homer, neuronal immediate early gene, 2