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Mammalian Monoclonal CASK Primary Antibody pour ISt, IHC - ABIN1304568
de Andrade, Kunzelman, Merrill, Fuerst: Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. dans Molecular vision 2014
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Rat (Rattus) Polyclonal CASK Primary Antibody pour WB - ABIN1881710
Butz, Okamoto, Südhof: A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. dans Cell 1998
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Dog (Canine) Monoclonal CASK Primary Antibody pour IF, IP - ABIN968174
Borg, Lõpez-Figueroa, de Taddèo-Borg, Kroon, Turner, Watson, Margolis: Molecular analysis of the X11-mLin-2/CASK complex in brain. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
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Rat (Rattus) Polyclonal CASK Primary Antibody pour WB - ABIN1742324
Sanford, Mays, Rafael-Fortney: CASK and Dlg form a PDZ protein complex at the mammalian neuromuscular junction. dans Muscle & nerve 2004
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Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling.
Full-length CASK-beta appears to have a unique role within central circuits that control motor output
Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII (Montrer CAMK2 Anticorps) to catalyze formation of a pool of calcium-insensitive CaMKII (Montrer CAMK2 Anticorps).
The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function.
the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo.
Dneurexin (DNRX (Montrer NRXN1 Anticorps)) is important for locomotion through a genetic interaction with the scaffold protein (Montrer HOMER1 Anticorps), CAKI/CMG, the Drosophila homolog of vertebrate CASK.
The CASK as a novel regulator of Cav1.2 (Montrer CACNA1C Anticorps) via a modulation of the voltage-gated calcium channel Cav1.2 (Montrer CACNA1C Anticorps) open probability.
findings demonstrate that microcephaly with pontine and cerebellar hypoplasia (MICPCH) is a genetically heterogeneous condition, in which CASK inactivating mutations appear to account for the majority of MICPCH cases and with severer phenotypes, while the non-CASK mutation cases tend to have milder microcephaly
we provide a further characterization of genotype-phenotype correlations in CASK mutations and the presentation of nystagmus and the FGS4 phenotype.
During atrial dilation/remodeling, CASK expression was reduced but its localization remained unchanged.
we report a patient presenting with a complex phenotype consisting of severe, adult-onset, dilated cardiomyopathy, hearing loss and developmental delay, in which exome sequencing revealed two genetic variants that are inherited from a healthy mother: a novel missense variant in the CASK gene, mutations in which cause a spectrum of neurocognitive manifestations
In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues, and its mRNA levels were inversely correlated with miR (Montrer MLXIP Anticorps)-203 expression.
Data indicate that patients with low calcium/calmodulin-dependent serine protein kinase (CASK) staining had a significantly better survival compared to patients with high CASK staining.
The findings suggest that CASK and the truncated prestin (Montrer SLC26A5 Anticorps) splice isoform contribute to confinement of prestin (Montrer SLC26A5 Anticorps) to the basolateral region of the plasma membrane.
CASK regulates CaMKII (Montrer CAMK2G Anticorps) autophosphorylation in a pathway required for memory formation.
a model whereby CASK recruits FRMD7 (Montrer FRMD7 Anticorps) to the plasma membrane to promote neurite outgrowth during development of the oculomotor neural network and that defects in this interaction result in nystagmus.
CASK phosphorylates neurexin (Montrer NRXN1 Anticorps), modulating the interaction of liprin (Montrer PPFIA1 Anticorps)-alpha with the CASK-neurexin1beta-Mint1 (Montrer APBA1 Anticorps) complex.
Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress.
DLG1 (Montrer DLG1 Anticorps) and CASK play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling
Immunofluorescence shows colocalization of Cx43 (Montrer GJA1 Anticorps) and CASK in brain astrocytes.
CASK negatively regulates PMCA4b (Montrer ATP2B4 Anticorps) by directly binding to it and JAM-A (Montrer F11R Anticorps) positively regulates it indirectly through CASK
Data show that CASK expression and the appropriate localization of DLG1 (Montrer DLG1 Anticorps) and LIN7c (Montrer LIN7C Anticorps) are not essential for either epithelial polarity or intestinal homeostasis in vivo.
Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation.
CASK is transcribed in mouse testis and processing may play a role in the acquisition of spserm and sperm functions.
CASK and Dlg (Montrer DLG4 Anticorps) may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction.
findings suggest that Cask plays an important role in all retinal synapses
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calcium/calmodulin-dependent protein kinase
, Camguk/CASK adaptor protein
, calmodulin-dependent kinase
, Peripheral plasma membrane protein CASK
, peripheral plasma membrane protein CASK
, calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase
, protein lin-2 homolog
, trinucleotide repeat containing 8
, G-protein-coupled receptor GPR34