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anti-Rat (Rattus) Prothrombin Anticorps:
anti-Mouse (Murine) Prothrombin Anticorps:
anti-Human Prothrombin Anticorps:
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Human Monoclonal Prothrombin Primary Antibody pour ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. dans The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody pour IF, WB - ABIN515438
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. dans PLoS ONE 2011
Human Polyclonal Prothrombin Primary Antibody pour IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. dans Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Human Polyclonal Prothrombin Primary Antibody pour CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. dans Shock (Augusta, Ga.) 2009
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (Montrer BGN Anticorps) plays a protective role during the progression of atherosclerosis in ApoE (Montrer APOE Anticorps)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (Montrer GP1BA Anticorps)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (Montrer MARK2 Anticorps) interaction regulated MCP-1 (Montrer CPT1B Anticorps), TF, MCSF (Montrer CSF1 Anticorps) and IL-6 (Montrer IL6 Anticorps) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (Montrer SERPINC1 Anticorps) nanoparticle therapeutics.
Thrombin-PAR1 (Montrer F2R Anticorps) signaling, via nitric oxide and EPCR (Montrer PROCR Anticorps), promotes hematopoietic stem cell (HSC (Montrer FUT1 Anticorps)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
thrombin/PAR1 (Montrer F2R Anticorps) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
The prevalence of FVL (Montrer F5 Anticorps) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (Montrer STXBP1 Anticorps)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (Montrer F5 Anticorps) mutation with ROP (Montrer STXBP1 Anticorps) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (Montrer F10 Anticorps) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (Montrer PROCR Anticorps) occupancy recruits G-protein coupled receptor kinase 5 (Montrer GRK5 Anticorps), thereby inducing beta-arrestin-2 (Montrer ARRB2 Anticorps) biased PAR1 (Montrer MARK2 Anticorps) signaling by both APC (Montrer APC Anticorps) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (Montrer F8 Anticorps) by thrombin has been presented.
These studies clarify the role of PKCdelta (Montrer PKCd Anticorps) in endothelial cell cytoskeleton regulation.
Findings indicate functional effects of thrombin allostery and suggest that individual active site-directed thrombin inhibitors uniquely modulate exosite function.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (Montrer SULF1 Anticorps) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (Montrer SULF1 Anticorps) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (Montrer MAPK1 Anticorps), MSK1 (Montrer RPS6KA5 Anticorps), and NF-kappaB (Montrer NFKB1 Anticorps) play important roles in thrombin-induced iNOS (Montrer NOS2 Anticorps) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (Montrer F2R Anticorps)) and thereby increasing the sensitivity of the myofilament to Ca(2 (Montrer CA2 Anticorps)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (Montrer UGDH Anticorps) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (Montrer F10 Anticorps) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (Montrer UGDH Anticorps) and by receptor-mediated up-regulation of factor XIII (Montrer UGDH Anticorps) synthesis
In conclusion, thrombin activates pro-MMP-2 (Montrer MMP2 Anticorps) in the absence of elevated pro-MMP-2 (Montrer MMP2 Anticorps) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (Montrer MMP2 Anticorps)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (Montrer F2R Anticorps), RhoA (Montrer RHOA Anticorps), and myocardin (Montrer MYOCD Anticorps).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA