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Chen, Teramura, Iwata: Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. dans Biomaterials 2011
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Lim, Joy, Hill, San Brian Chia: Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease. dans European journal of medicinal chemistry 2011
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Mouse (Murine) Prothrombin Kit ELISA pour Sandwich ELISA - ABIN2010738
Wang, Braun, Zhang, Norström, Thorlacius: Thrombin generation in abdominal sepsis is Rho-kinase-dependent. dans Biochemical and biophysical research communications 2015
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Human Prothrombin Kit ELISA pour Sandwich ELISA - ABIN612790
Badimon, Badimon, Turitto, Vallabhajosula, Fuster: Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. dans Circulation 1989
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Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (Montrer BGN Kits ELISA) plays a protective role during the progression of atherosclerosis in ApoE (Montrer APOE Kits ELISA)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (Montrer GP1BA Kits ELISA)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (Montrer MARK2 Kits ELISA) interaction regulated MCP-1 (Montrer CPT1B Kits ELISA), TF, MCSF (Montrer CSF1 Kits ELISA) and IL-6 (Montrer IL6 Kits ELISA) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (Montrer SERPINC1 Kits ELISA) nanoparticle therapeutics.
Thrombin-PAR1 (Montrer F2R Kits ELISA) signaling, via nitric oxide and EPCR (Montrer PROCR Kits ELISA), promotes hematopoietic stem cell (HSC (Montrer FUT1 Kits ELISA)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (Montrer CDC25C Kits ELISA) and Ras-associating domains of phospholipase C epsilon (Montrer PLCE1 Kits ELISA).
thrombin/PAR1 (Montrer F2R Kits ELISA) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
The prevalence of FVL (Montrer F5 Kits ELISA) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (Montrer STXBP1 Kits ELISA)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (Montrer F5 Kits ELISA) mutation with ROP (Montrer STXBP1 Kits ELISA) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (Montrer F10 Kits ELISA) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (Montrer PROCR Kits ELISA) occupancy recruits G-protein coupled receptor kinase 5 (Montrer GRK5 Kits ELISA), thereby inducing beta-arrestin-2 (Montrer ARRB2 Kits ELISA) biased PAR1 (Montrer MARK2 Kits ELISA) signaling by both APC (Montrer APC Kits ELISA) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (Montrer F8 Kits ELISA) by thrombin has been presented.
These studies clarify the role of PKCdelta (Montrer PKCd Kits ELISA) in endothelial cell cytoskeleton regulation.
Findings indicate functional effects of thrombin allostery and suggest that individual active site-directed thrombin inhibitors uniquely modulate exosite function.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (Montrer SULF1 Kits ELISA) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (Montrer SULF1 Kits ELISA) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (Montrer MAPK1 Kits ELISA), MSK1 (Montrer RPS6KA5 Kits ELISA), and NF-kappaB (Montrer NFKB1 Kits ELISA) play important roles in thrombin-induced iNOS (Montrer NOS2 Kits ELISA) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (Montrer F2R Kits ELISA)) and thereby increasing the sensitivity of the myofilament to Ca(2 (Montrer CA2 Kits ELISA)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (Montrer UGDH Kits ELISA) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (Montrer F10 Kits ELISA) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (Montrer UGDH Kits ELISA) and by receptor-mediated up-regulation of factor XIII (Montrer UGDH Kits ELISA) synthesis
In conclusion, thrombin activates pro-MMP-2 (Montrer MMP2 Kits ELISA) in the absence of elevated pro-MMP-2 (Montrer MMP2 Kits ELISA) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (Montrer MMP2 Kits ELISA)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (Montrer F2R Kits ELISA), RhoA (Montrer RHOA Kits ELISA), and myocardin (Montrer MYOCD Kits ELISA).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA