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anti-Human Filamin A Anticorps:
anti-Rat (Rattus) Filamin A Anticorps:
anti-Mouse (Murine) Filamin A Anticorps:
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Human Monoclonal Filamin A Primary Antibody pour IHC (p), PLA - ABIN560922
Valente, Logan, Mougou-Zerelli, Lee, Silhavy, Brancati, Iannicelli, Travaglini, Romani, Illi, Adams, Szymanska, Mazzotta, Lee, Tolentino, Swistun, Salpietro, Fede, Gabriel, Russ, Cibulskis, Sougnez et al.: Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. ... dans Nature genetics 2010
Show all 8 Pubmed References
Human Monoclonal Filamin A Primary Antibody pour WB - ABIN1882243
Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. dans The Journal of cell biology 1990
Show all 6 Pubmed References
Human Polyclonal Filamin A Primary Antibody pour ICC, IF - ABIN188803
Thoms, Loveridge, Simpson, Clipson, Reinhardt, Dunlop, Stark: Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. dans Cancer research 2010
Show all 2 Pubmed References
Knockdown of filamin A or vimentin (Montrer VIM Anticorps) in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.
Here we show using Drosophila indirect flight mus (Montrer KPTN Anticorps)cle that t (Montrer FLNC Anticorps)he filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the (Montrer TTN Anticorps) titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.
study identifies Cher as a new target of JNK (Montrer MAPK8 Anticorps) signaling that links cytoskeleton dynamics to tumor progression.
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
Filamin is required for ovarian follicle cell motility during oogenesis.
FLNA upregulation correlates with Snail (Montrer SNAI1 Anticorps)-induced epithelial to mesenchymal transition in colorectal carcinoma.
Our findings expand the male-specific phenotype of FLNA mutations that now includes classical-like EDS with lethal cardiac valvular dystrophy, and offer further insights for the genotype-phenotype correlations within this spectrum.
Study identifies ANXA4 (Montrer ANXA4 Anticorps) and FLNA as up-regulated in buccal squamous cell carcinoma arising from oral submucous fibrosis.
These results provide new insights into the regulation of SK2 (Montrer KCNN2 Anticorps) channel trafficking by the cytoskeletal proteins FLNA and alpha-actinin2, involving distinct recycling pathways
Respiratory failure secondary to progressive obstructive lung disease during infancy may be the presenting phenotype of FLNA-associated periventricular nodular heterotopia.
The actin regulator FLNA interacts with the endoplasmic reticulum stress kinase PERK and this interaction is required for the efficient formation of ER-plasma membrane contact sites.
CCR2B (Montrer CCR2 Anticorps) and beta2AR (Montrer ADRB2 Anticorps) signals to FLNa to stimulate its endocytosis and recycling to the plasma membrane.
In humans, mutations in the actin-binding protein (Montrer KPTN Anticorps) Filamin-C (Montrer FLNC Anticorps) result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin (Montrer TTN Anticorps) plays a crucial role in keeping thin filaments stably anchored at the Z-disc
Case Report: Reduced binding of mutant FLNa to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.
results reveal an unusual structural and thermodynamic basis for the P2204L-induced dysfunction of filamin and frontometaphyseal dysplasia disease.
filamin reduces ENaC (Montrer SCNN1A Anticorps) channel function through direct interaction on the cell surface
Here the authors report that intermediate progenitor's neuron production is enhanced by abrogating filamin function, leading to the generation of periventricular neurons independent of normal neocortical neurogenesis and neuronal migration.
These results show that FLNA plays crucial roles in asymmetric division during meiotic maturation by regulating ROCK-cofilin-mediated actin reorganization.
FlnA binding to PACSIN2 (Montrer PACSIN2 Anticorps) F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
FlnA is a critical upstream element of the signaling cascade underlying the myogenic tone.
Bones lacking filamin A are protected from estrogen-mediated post-menopausal osteoporosis
findings suggest a model in which filamin A local translation following axon injury controls localized HDAC5 (Montrer HDAC5 Anticorps) activity to promote axon regeneration.
Deletion of filamin A in endothelial cells aggravated myocardial infarction-induced left ventricle dysfunction and cardiac failure as a result of defective endothelial response
A new signaling set, phosphatidic acid-S6K1-FLNA-actin, sheds light into the morphogenic pathway of cytoskeletal structures that are crucial for adhesion and cell locomotion during inflammation and metastasis.
Filamin-A is associated with neutrophil uropod retraction.
Analysis of editing in the filamin A encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA editing is mainly achieved by ADAR2 (Montrer ADARB1 Anticorps) but that in some cases ADAR1 (Montrer ADAR Anticorps) can efficiently compensate for ADAR2 (Montrer ADARB1 Anticorps).
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
, filamin A, alpha (actin binding protein 280)
, filamin B, like
, filamin A, alpha
, filamin B
, filamin isoform B
, shi kong
, actin binding protein 280
, endothelial actin-binding protein
, non-muscle filamin
, Endothelial actin-binding protein 280)
, filamin, alpha
, 450 kDa protein
, GENA 379
, actin-binding protein 280
, dilated pupils 2
, filamin A