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Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (Montrer CD6 Kits ELISA) and linker for activation of T cells protein (LAT (Montrer ORC3 Kits ELISA)) phosphotyrosine (pTyr) peptides.
High expression of LAT1 and ASCT2 (Montrer SLC1A5 Kits ELISA) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (Montrer IFT20 Kits ELISA) is required for the delivery of the intracellular pool of LAT (Montrer ORC3 Kits ELISA) to the immune synapse in naive primary T lymphocytes.
Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen (Montrer CD59 Kits ELISA) in T cells.
HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 (Montrer IL2 Kits ELISA) production by inactivation of the linker for activation of T cells.
Patients with severe aplastic anemia had increased levels of LAT (Montrer ORC3 Kits ELISA) and disturbed Th1 (Montrer TH1L Kits ELISA)-Th2 balance.
LAT (Montrer ORC3 Kits ELISA) is a modulator of CD3zeta (Montrer CD247 Kits ELISA) and ZAP-70 (Montrer ZAP70 Kits ELISA) tyrosine phosphorylation.
mutation of palmitoylation site of LAT (Montrer ORC3 Kits ELISA)-EGFP attenuated the signal transduction of CD59 (Montrer CD59 Kits ELISA) in T cells
findings show that L-type amino acid transporter 1 (Montrer SLC7A5 Kits ELISA) is a major transporter for essential amino acids into activated human T cells
Histone hypoacetylation on LAT (Montrer ORC3 Kits ELISA) promoter could inhibit LAT (Montrer ORC3 Kits ELISA) expression and enhanced Th2 differentiation, while trichostatin A, a histone deacetylase (Montrer HDAC1 Kits ELISA) inhibitor, promoted LAT (Montrer ORC3 Kits ELISA) expression and inhibited Th2 cytokine production
IFT20 (Montrer IFT20 Kits ELISA) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (Montrer MLXIP Kits ELISA)-155 regulates the delicate balance between PAK1 (Montrer PAK1 Kits ELISA)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (Montrer CD28 Kits ELISA) and the TCR complex regulate NF-kappaB (Montrer NFKB1 Kits ELISA) via different signaling modules of GRB-2 (Montrer GRB2 Kits ELISA)/VAV1 (Montrer VAV1 Kits ELISA) and LAT/ADAP (Montrer APP Kits ELISA) pathways respectively.
The result indicate that LAT-PLCg1 (Montrer PLCG1 Kits ELISA) interaction is important for controlling IL-6 (Montrer IL6 Kits ELISA) production by T cells and demonstrate a critical role of IL-6 (Montrer IL6 Kits ELISA) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (Montrer PLCG1 Kits ELISA) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (Montrer PLCG1 Kits ELISA) in Dow2-induced anergic T cells. The novel CD3 (Montrer CD3E Kits ELISA)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (Montrer SOS1 Kits ELISA) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (Montrer ZAP70 Kits ELISA)-Lat-SLP-76 (Montrer LCP2 Kits ELISA) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (Montrer PLCG1 Kits ELISA)) signaling may function differently in various subsets of gammadelta T cells.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein