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LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity
Here we report that phosphotyrosine-mediated assembly of adaptor protein LAT networks yields two distinct kinetic species of the Ras activator SOS
Overexpression of LAT (Montrer ORC3 Kits ELISA) is associated with microcephaly.
LAT (Montrer ORC3 Kits ELISA) and SLP-76 (Montrer LCP2 Kits ELISA) are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
this study shows that inherited LAT (Montrer ORC3 Kits ELISA) deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
This is the first report of a LAT (Montrer ORC3 Kits ELISA)-related disease in humans, manifesting by a progressive combined immune deficiency with severe autoimmune disease.
Data show that LAT1 plays an important role in regulating the uptake of essential amino acids such as leucine into endometrial cancer cells. Increased ability of BCH (Montrer CHN2 Kits ELISA) compared to LAT1 shRNA at inhibiting Ishikawa spheroid area suggests that other LAT (Montrer ORC3 Kits ELISA) family members may also contribute to cell growth.
Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (Montrer CD6 Kits ELISA) and linker for activation of T cells protein (LAT (Montrer ORC3 Kits ELISA)) phosphotyrosine (pTyr) peptides.
High expression of LAT1 and ASCT2 (Montrer SLC1A5 Kits ELISA) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (Montrer IFT20 Kits ELISA) is required for the delivery of the intracellular pool of LAT (Montrer ORC3 Kits ELISA) to the immune synapse in naive primary T lymphocytes.
this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
IFT20 (Montrer IFT20 Kits ELISA) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (Montrer MLXIP Kits ELISA)-155 regulates the delicate balance between PAK1 (Montrer PAK1 Kits ELISA)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (Montrer CD28 Kits ELISA) and the TCR complex regulate NF-kappaB (Montrer NFKB1 Kits ELISA) via different signaling modules of GRB-2 (Montrer GRB2 Kits ELISA)/VAV1 (Montrer VAV1 Kits ELISA) and LAT/ADAP (Montrer APP Kits ELISA) pathways respectively.
The result indicate that LAT-PLCg1 (Montrer PLCG1 Kits ELISA) interaction is important for controlling IL-6 (Montrer IL6 Kits ELISA) production by T cells and demonstrate a critical role of IL-6 (Montrer IL6 Kits ELISA) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (Montrer PLCG1 Kits ELISA) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (Montrer PLCG1 Kits ELISA) in Dow2-induced anergic T cells. The novel CD3 (Montrer CD3E Kits ELISA)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (Montrer SOS1 Kits ELISA) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (Montrer ZAP70 Kits ELISA)-Lat-SLP-76 (Montrer LCP2 Kits ELISA) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (Montrer PLCG1 Kits ELISA)) signaling may function differently in various subsets of gammadelta T cells.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein