Aperçu des produits pour MAP3K4 Protéines (MAP3K4)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 4 Protéines (MAP3K4)
Chez www.anticorps-enligne.fr sont 5 Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Protéines de 3 de différents fournisseurs disponibles. De plus, nous expédions MAP3K4 Anticorps (81) et beaucoup plus de produits pour cette protéine. Un total de 90 MAP3K4 produits sont actuellement listés.
D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, Tas
afficher tous les protéines Gène GeneID UniProt
MAP3K4 308106  
MAP3K4 4216 Q9Y6R4
MAP3K4 26407 O08648

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MAP3K4 Protéines (MAP3K4) par origine

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Human Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. IL-21 (Montrer IL17C Protéines) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma

  2. Mutations in genes such as AKT2 (Montrer AKT2 Protéines), CCNA1 (Montrer CCNA1 Protéines), MAP3K4, and TGFBR1 (Montrer TGFBR1 Protéines), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.

  3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  4. MTK1 was identified in the HER2 (Montrer ERBB2 Protéines)/HER3 (Montrer ERBB3 Protéines)-HRG (Montrer NRG1 Protéines) mediated extracellular acidification and cell migration pathway in breast cancer cells.

  5. MAP3K4 is sufficiently mediate the TGFbeta (Montrer TGFB1 Protéines)-induced phosphorylation of p38 MAPK (Montrer MAPK14 Protéines) in MEFs and HaCaT cells.

  6. we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease.

  7. For the first time we report a significant association between nicotine dependence and DRD5 (Montrer DRD5 Protéines), NPY1R (Montrer NPY1R Protéines) MAP3K4 single nucleotide polymorphism.

  8. The upstream molecule of the TRAIL-induced MAPK (Montrer MAPK1 Protéines) activation is MEKK (Montrer MAP3K1 Protéines), as opposed to ASK1 (Montrer MAP3K5 Protéines), via the mediation of its signal through JNK (Montrer MAPK8 Protéines)/p38 (Montrer CRK Protéines) in a caspase-8 (Montrer CASP8 Protéines)-dependent manner.

  9. CIN85 (Montrer SH3KBP1 Protéines) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4

  10. Axin (Montrer AXIN1 Protéines) utilizes distinct regions for competitive MEKK1 (Montrer MAP3K1 Protéines) and MEKK4 binding and JNK (Montrer MAPK8 Protéines) activation.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a (Montrer GADD45A Protéines) increases MEKK4 protein kinase (Montrer CDK7 Protéines) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a (Montrer GADD45A Protéines)-mediated skeletal muscle fiber atrophy.

  2. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  3. suggest a requirement for GADD45gamma (Montrer GADD45G Protéines) in promoting MAP3K4-mediated activation of p38 MAPK (Montrer MAPK14 Protéines) signaling in embryonic gonadal somatic cells for testis determination

  4. MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.

  5. During Th1 (Montrer HAND1 Protéines) differentiation, the GADD45beta (Montrer GADD45B Protéines)/GADD45gamma (Montrer GADD45G Protéines)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (Montrer IL12A Protéines)/STAT4 (Montrer STAT4 Protéines), leading to augmented interferon-gamma (Montrer IFNG Protéines) production in a process independent of STAT4 (Montrer STAT4 Protéines).

  6. MEKK4 plays a critical role in regulating MKK4 (Montrer MAP2K4 Protéines) activity and apoptotic cell death during neural tube development.

  7. MEKK4 is the MAPK (Montrer MAPK1 Protéines) kinase kinase for TRAF4 (Montrer TRAF4 Protéines) regulation of the JNK (Montrer MAPK8 Protéines) pathway

  8. Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (Montrer MAP2K3 Protéines) and -6, mitogen-activated protein kinase (Montrer MAPK1 Protéines) kinases (MKKs (Montrer MKKS Protéines)) regulated by MEKK4 in the p38 (Montrer CRK Protéines) pathway.

  9. MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.

  10. our results demonstrate a link between MEKK4 and filamin-a (Montrer FLNA Protéines) that impacts neuronal migration initiation

Profil protéine MAP3K4

Profil protéine

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

Alternative names and synonyms associated with MAP3K4

  • mitogen activated protein kinase kinase kinase 4 (Map3k4)
  • mitogen-activated protein kinase kinase kinase 4 (MAP3K4)
  • mitogen-activated protein kinase kinase kinase 4 (Map3k4)
  • D17Rp17 Protéine
  • D17Rp17e Protéine
  • MAPKKK4 Protéine
  • Mek4b Protéine
  • MEKK 4 Protéine
  • Mekk4 Protéine
  • mKIAA0213 Protéine
  • MTK1 Protéine
  • PRO0412 Protéine
  • RP17 Protéine
  • Rp17a Protéine
  • Tas Protéine

Protein level used designations for MAP3K4

mitogen-activated protein kinase kinase kinase 4 , MAP three kinase 1 , MAP/ERK kinase kinase 4 , MAPK/ERK kinase kinase 4 , MEK kinase 4 , MEKK 4 , SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of , dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) , predicted protein of HQ0412 , T-associated sex reversal , mitogen activated protein kinase kinase kinase 4

308106 Rattus norvegicus
4216 Homo sapiens
26407 Mus musculus
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