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anti-Rat (Rattus) MAP4K1 Anticorps:
anti-Human MAP4K1 Anticorps:
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Human Polyclonal MAP4K1 Primary Antibody pour ELISA, WB - ABIN249544
Hu, Qiu, Wang, Meyer, Tan: Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. dans Genes & development 1996
CUL7 (Montrer CUL7 Anticorps)/Fbxw8 (Montrer FBXW8 Anticorps) ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7 (Montrer CUL7 Anticorps)/Fbxw8 (Montrer FBXW8 Anticorps) ubiquitin ligase in the MAPK (Montrer MAPK1 Anticorps) pathway, which plays a critical role in cell proliferation and differentiation.
HPK1 is critically involved in LFA-1 (Montrer ITGAL Anticorps)-mediated polymorphonuclear neutrophils trafficking during acute inflammation.
results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia (Montrer BCL11A Anticorps) cells, but the cleaved HPK1 fragment inhibits differentiation
Pdcd4 (Montrer PDCD4 Anticorps) knockdown up-regulates MAP kinase (Montrer MAPK1 Anticorps) kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun (Montrer JUN Anticorps).
QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased.
HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters.
The purpose of the study was to investigate the potential contribution of HPK1, MEKK1 (Montrer MAP3K1 Anticorps), TAK1 (Montrer MAP3K7 Anticorps), p-MKK4 (Montrer MAP2K4 Anticorps) to the development of extramammary Paget disease
The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription.
PP4 (Montrer ANXA5 Anticorps) is a positive regulator for HPK1 and the HPK1-JNK (Montrer MAPK8 Anticorps) signaling pathway
Full activation of HPK1 is dependent on autophosphorylation of threonine 165 and phosphorylation of serine 171, which is a target site for protein kinase D (PKD) in vitro.
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin (Montrer CTTN Anticorps) binding of HPK1 peptide.
a novel negative feedback regulation of BCR (Montrer BCR Anticorps) signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK (Montrer BLNK Anticorps)
HPK1 associates with SKAP1 (Montrer SKAP1 Anticorps) to negatively regulate Rap1 (Montrer TERF2IP Anticorps)-mediated B-lymphocyte (Montrer AKAP17A Anticorps) adhesion.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Hpk1 supports apoptosis of T lymphocytes by inhibiting the antiapoptotic action of NF-kappaB (Montrer NFKB1 Anticorps) and inducing the proapoptotic activity of JNK (Montrer MAPK8 Anticorps).
Mona/Gads (Montrer GRAP2 Anticorps) SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death
HPK1-C as a suppressor of antiapoptotic Bcl-2 (Montrer BCL2 Anticorps) proteins and provide a molecular basis for our understanding of CD95L (Montrer FASL Anticorps)-independent activation-induced cell death of lymphocytes.
Our data reveal a novel role for HPK1 as a negative regulator of dendritic cell functions
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
mitogen-activated protein kinase kinase kinase kinase 1
, MAPK/ERK kinase kinase kinase 1
, MEK kinase kinase 1
, MEKKK 1
, hematopoietic progenitor kinase 1
, mitogen activated protein kinase kinase kinase kinase 1