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xPontin and xReptin are essential genes regulating cell proliferation in early Xenopus embryogenesis through interaction with c-Myc (Montrer MYC Kits ELISA)
Reptin silencing did not affect the tyrosine phosphorylation of the insulin receptor (Montrer INSR Kits ELISA) nor of IRS1 (Montrer IRS1 Kits ELISA), but it enhanced the tyrosine phosphorylation of the p85 subunit of PI3K (Montrer PIK3CA Kits ELISA).
Overall, POLG (Montrer POLG Kits ELISA) interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2.
The authors report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions.
by means of molecular docking approaches we first modeled the structures of hetero-hexameric TIP49 ( TIP49a and TIP49b )complexes with short ds-DNA fragments (20 base pairs with different GC content) within the central channel of hexameric ring
Data suggest that overexpression of Reptin in hepatocellular carcinoma (HCC (Montrer FAM126A Kits ELISA)) could be a factor of resistance to treatment.
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
results reveal a novel mechanism for the control of NF-kappaB (Montrer NFKB1 Kits ELISA) pathway by cytoplasmic Reptin
The results suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of Fanconi anaemia core complex.
Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction.
these findings suggest that YY1 (Montrer YY1 Kits ELISA)-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we show that YY1 (Montrer YY1 Kits ELISA) and the ATPase (Montrer DNAH8 Kits ELISA) activity of RuvBL2 are required for RAD51 (Montrer RAD51 Kits ELISA) foci formation during homologous recombination.
the Reptin-Lrrc6/Seahorse (Montrer LRRC6 Kits ELISA) complex is involved in dynein arm formation.
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin (Montrer CTNNB1 Kits ELISA) pathway
Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
accumulating E2f1 (Montrer E2F1 Kits ELISA) progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f (Montrer E2F1 Kits ELISA) target genes and amplifies the E2f (Montrer E2F1 Kits ELISA) transcriptional response.
Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4 (Montrer POU5F1 Kits ELISA)-mediated gene regulation
Gata3 (Montrer GATA3 Kits ELISA)/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c (Montrer CDKN2C Kits ELISA) expression.
We demonstrate that leukemogenic activity of MLL (Montrer MLL Kits ELISA)-AF9 (Montrer MLLT3 Kits ELISA) requires RUVBL2 (RuvB-like 2), an AAA (Montrer AAAS Kits ELISA)+ ATPase (Montrer DNAH8 Kits ELISA) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.
A forward genetic screen reveals roles for Nfkbid, Zeb1 (Montrer ZEB1 Kits ELISA), and Ruvbl2 in humoral immunity.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Reptin, a chromatin-remodeling factor (Montrer ASH1L Kits ELISA), is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a (Montrer EHMT2 Kits ELISA).
RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells.
RUVBL2 plays an important role in insulin-stimulated GLUT4 translocation through its interaction with AS160
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
RuvB-like protein 2
, RuvB-like 2
, RuvB-like 2 (E. coli)
, ruvB-like 2-like
, ruvb-like 2
, ruvB-like 2
, 48 kDa TATA box-binding protein-interacting protein
, 48 kDa TBP-interacting protein
, 51 kDa erythrocyte cytosolic protein
, INO80 complex subunit J
, RuvB (E coli homolog)-like 2
, TIP60-associated protein 54-beta
, erythrocyte cytosolic protein, 51-KD
, repressing pontin 52
, reptin52 protein