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our findings demonstrate that ARF1 is a molecular switch for cancer progression and thus suggest that limiting the expression/activation of this GTPase (Montrer RACGAP1 Kits ELISA) could help improve outcome for breast cancer patients.
changes in distinct lipid ratios may converge on ARF1 to increase SBP-1 (Montrer MEGF8 Kits ELISA)/SREBP-1 (Montrer SREBF1 Kits ELISA) activity.
Experiments using a mutant form of ARF1 affecting GTP (Montrer AK3 Kits ELISA) hydrolysis suggest that ARF1[GTP (Montrer AK3 Kits ELISA)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (Montrer PLIN2 Kits ELISA) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (Montrer PLIN2 Kits ELISA) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM-DR by regulating phosphorylation of p27 (Montrer PAK2 Kits ELISA) at T157 in MM. our data shed new light on the molecular mechanism of CAM-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (Montrer COPA Kits ELISA)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (Montrer ST8SIA2 Kits ELISA)-induced apoptosis. M-COPA (Montrer COPA Kits ELISA) inhibited transport of Stx (Montrer ST8SIA2 Kits ELISA) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (Montrer ARF3 Kits ELISA) as well as Arf6 (Montrer ARF6 Kits ELISA) play important roles in cytokinesis.
ARF1 activates the MAPK (Montrer MAPK1 Kits ELISA) pathway likely using the Golgi as a main platform, which in turn activates the cytoplasmic RSK1 (Montrer RPS6KA1 Kits ELISA), leading to cell proliferation.
Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A (Montrer CHGA Kits ELISA) and regulates secretion of insulin like growth factor 1 (IGF-1 (Montrer IGF1 Kits ELISA)) and is required for anchorage dependent growth.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (Montrer TP53 Kits ELISA) delays age-associated central nervous system functional decline.
ARF1/TBCE (Montrer TBCE Kits ELISA)-mediated cross-talk that coordinates COPI formation and tubulin (Montrer TUBB Kits ELISA) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (Montrer LRP6 Kits ELISA) phosphorylation for the transduction of Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (Montrer AK3 Kits ELISA) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (Montrer AK3 Kits ELISA)
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (Montrer NCS1 Kits ELISA) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (Montrer KDR Kits ELISA) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (Montrer NOS3 Kits ELISA) activation and nitric oxide release from endothelial cells
Data show that AP-1 (Montrer JUN Kits ELISA) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (Montrer AK3 Kits ELISA) or nonhydrolyzable GTP (Montrer AK3 Kits ELISA)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (Montrer NCS1 Kits ELISA)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (Montrer CA2 Kits ELISA)+)-dependent and ARF-dependent pathways in TGN (Montrer TG Kits ELISA) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (Montrer JUN Kits ELISA) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (Montrer AK3 Kits ELISA).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (Montrer ARF5 Kits ELISA)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (Montrer ARF5 Kits ELISA) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1
, ADP-ribosylation factor domain protein 1