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The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.
ZIP5 is directed to the same subcellular locations as PrP(C (Montrer PRNP Kits ELISA)) and both proteins are seen to be endocytosed through vesicles decorated with the Rab5 (Montrer RAB5A Kits ELISA) marker protein.
miR (Montrer MLXIP Kits ELISA)-328 and miR (Montrer MLXIP Kits ELISA)-193a are expressed in tissues known to regulate Zip5 mRNA translation in response to zinc availability and both are polysome-associated consistent with Zip5 mRNA localization
Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells
ZIP4 (Montrer SLC39A4 Kits ELISA) and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5]
temporal and spatial patterns of expression of the mouse ZIP1 (Montrer SLC39A1 Kits ELISA), 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined
Zip5 mRNA abundance does not change in response to zinc, but the translation of this mRNA was found to be zinc-responsive
we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2 (Montrer COX2 Kits ELISA), and promoted the expression of E-cadherin (Montrer CDH1 Kits ELISA).
ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2 (Montrer COX2 Kits ELISA), cyclin D1 (Montrer CCND1 Kits ELISA) and E-cadherin (Montrer CDH1 Kits ELISA) expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma .
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A5 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003
zinc transporter ZIP5
, solute carrier family 39 member 5
, zrt- and Irt-like protein 5
, solute carrier family 39 (metal ion transporter), member 5