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AGPAT1 encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). De plus, nous expédions 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) Anticorps (45) et 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) Kits (18) et beaucoup plus de produits pour cette protéine.
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The differences in expression of AGPAT1 in human monocytes and macrophages, and its effect on platelet-activating factor in these cells is reported.
Results suggest that motifs II and III of 1-acyl-sn-glycero-3-phosphate acyltransferase 1 are involved in lysophosphatidic acid binding, and motifs I and IV are involved in acyl-CoA (Montrer GNPAT Protéines) binding.
Activation of lysophosphatidic acid-fatty acid transacylase (LPAAT) is essential but not sufficient for thrombin (Montrer F2 Protéines)-induced smooth muscle cell proliferation.
Agpat1-/- mice developed widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. AGPAT1 appears to serve important functions in the physiology of multiple organ systems. The Agpat1-deficient mouse provides an important model in which to study the contribution of phospholipid and triacylglycerol synthesis to physiology and diseases.
observations strongly implicate AGPAT1 in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton
mtGPAT1 might serve as a novel target for treatment of hepatic steatosis and hepatic insulin (Montrer INS Protéines) resistance and that long chain acyl-CoA's do not mediate fat-induced hepatic insulin (Montrer INS Protéines) resistance in this model.
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.
1-AGP acyltransferase 1
, 1-AGPAT 1
, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
, 1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase)
, 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
, lysophosphatidic acid acyltransferase alpha
, lysophospholipid acyltransferase
, lysophosphatidic acid-fatty acid transacylase
, lyosphosphatidic acid acyltransferase