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SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. De plus, nous expédions XRN1 Protéines (5) et XRN1 Kits (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal XRN1 Primary Antibody pour IP, PLA - ABIN153005
Ozgur, Chekulaeva, Stoecklin: Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies. dans Molecular and cellular biology 2010
Show all 6 Pubmed References
Insertion of 5'-3' exoribonuclease 1 (XRN1)-resistant sequences (xrRNAs) into different reporter mRNAs allowed to monitor RNA decay activity by the nonsense-mediated mRNA decay pathway (NMD).
These findings suggest that sequestration of the exoribonucleases DIS3L2 (Montrer DIS3L2 Anticorps) and XRN1 to nuclear inclusions may be related to the pathogenesis of intranuclear inclusion body disease
Data show that the AR-miR (Montrer MLXIP Anticorps)-204-XRN1-miR (Montrer MLXIP Anticorps)-34a positive feedback loop and a dual function of miR (Montrer MLXIP Anticorps)-204/XRN1 axis in prostate cancer.
Thus, Xrn1 is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors.
Occupation of each miR (Montrer MLXIP Anticorps)-122 binding site on 5' untranslated region of the hepatitis C virus genome contributes equally and cooperatively to virus replication via protecting from Xrn1 exoribonuclease degradation.
Authors conclude that Xrn1 is the dominant 5' exoribonuclease mediating decay of hepatitis C virus RNA and that miR (Montrer MLXIP Anticorps)-122 provides protection against it
Mouse Xrn1 plays a role in RNA turnover.
Data show that 5' exonuclease (Montrer EXO1 Anticorps) Xrn1 knockdown and miR (Montrer MLXIP Anticorps)-122 supplementation have equal, redundant, and nonadditive effects on the rate of viral RNA decay, indicating that miR (Montrer MLXIP Anticorps)-122 protects HCV RNA from 5' decay.
findings reveal a role for XRN1 in decapping and provide a molecular basis for the coupling of decapping to 5'-->3' mRNA degrada
LSm1 (Montrer LSM1 Anticorps)-7 proteins colocalize with DCP1 (Montrer ACE Anticorps),DCP2 (Montrer DCP2 Anticorps) and Xrn1 in cytoplasmic foci
XRN1 knockdown impairs the translational repression triggered by NMDA. Collectively, these observations support a role for the SX-bodies in the reversible masking and silencing of mRNAs at the synapse.
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.
5'-3' exoribonuclease 1
, strand-exchange protein 1 homolog
, protein Dhm2