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XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. De plus, nous expédions XRN2 Kits (3) et XRN2 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal XRN2 Primary Antibody pour ICC, IF - ABIN252879
Barnhart, Moon, Emch, Wilusz, Wilusz: Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus. dans Cell reports 2013
depletion of NKRF (Montrer NKRF Anticorps), XRN2 or DHX15 (Montrer DHX15 Anticorps) impairs an early pre-rRNA cleavage step.
XRN2 is a novel regulator of EMT (Montrer ITK Anticorps) that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism.
XRN2 has a role in R-loop resolution, suppression of replication stress, and maintenance of genomic stability
Chromatin immunoprecipitation experiments further show that IL-1 (Montrer IL1A Anticorps) stimulation leads to decrease in NKRF (Montrer NKRF Anticorps) aa 421-429 phosphorylation and dissociation of NELF-E (Montrer RDBP Anticorps) and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter
P-TEFb (Montrer CCNT1 Anticorps) regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.
The results suggest that CARF (Montrer CDKN2AIP Anticorps) regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.
Kinetic competition between elongating pol II (Montrer 0 Anticorps) and the Xrn2 exonuclease (Montrer EXO1 Anticorps) is integral to termination of transcription on most human genes.
found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1 (Montrer RNASEH1 Anticorps)-mediated cleavage
The restriction of JFH1 and H77D hepatitis C virus replication by Xrn2 is likely indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses.
Xrn2 has a cytoplasmic, antiviral function against HCV that is counteracted by HCV's subversion of miR (Montrer MLXIP Anticorps)-122 to form a protective oligomeric complex at the 5' end of the viral genome.
Nkx2-5 (Montrer NKX2-5 Anticorps) genetically interacts with Xrn2 because Nkx2-5 (Montrer NKX2-5 Anticorps)(+/-)Xrn2(+/-), but neither Nkx2-5 (Montrer NKX2-5 Anticorps)(+/-)nor Xrn2(+/-), newborns exhibited a defect in ventricular septum formation, suggesting that the association between Nkx2-5 (Montrer NKX2-5 Anticorps) and Xrn2 is essential for heart development.
Genetic variants regulating Xrn2 expression in cis (Montrer CISH Anticorps) are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.
AtXRN2 has a role in ribosomal RNA processing.
The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 are endogenous posttranscriptional gene silencing suppressors.
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene\; however, their full-length nature is not known.
5'-3' exoribonuclease 2
, 5'-3' exoribonuclease 2-like
, DHP protein
, Dhm1-like protein (mouse homolog)
, protein Dhm1