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ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. De plus, nous expédions ATIC Protéines (12) et et beaucoup plus de produits pour cette protéine.
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Fruit Fly (Drosophila melanogaster) Monoclonal ATIC Primary Antibody pour IHC (p), WB - ABIN2477543
Rattan, Giri, Singh, Singh: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. dans The Journal of biological chemistry 2005
The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study.
Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy
The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.
ATIC 347C>G gene polymorphism may be associated with the development of MTX (Montrer MTX1 Anticorps) induced gastrointestinal adverse events.
genotyping of ATIC rs2372536 and ITPA (Montrer ITPA Anticorps) rs1127354 variants or measuring ITPA (Montrer ITPA Anticorps) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.
This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (Montrer GGH Anticorps) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma
Our data show that ATIC is in complex with insulin receptor (IR (Montrer INSR Anticorps))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (Montrer INS Anticorps) stimulation and ATIC knockdown readily increase level of AMPK (Montrer PRKAA1 Anticorps)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (Montrer INS Anticorps) response of Glut2 (Montrer SLC2A2 Anticorps) translocation in HEK293 cells and decreased AKT (Montrer AKT1 Anticorps)-Ser473 phosphorylation.
Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.
MTHFR (Montrer MTHFR Anticorps), DHFR (Montrer DHFR Anticorps) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (Montrer MTX1 Anticorps) monotherapy.
study suggests that MTHFR (Montrer MTHFR Anticorps) C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX (Montrer MTX1 Anticorps) treatment and, therefore, assist clinicians in personalizing RA treatment
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
bifunctional purine biosynthesis protein PurH
, bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein PurH
, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
, bifunctional purine biosynthesis protein PURH
, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
, 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC
, aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase
, aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase
, bifunctional purine biosynthesis protein