anti-5'-Nucleotidase, Cytosolic II (NT5C2) Anticorps

NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. De plus, nous expédions 5'-Nucleotidase, Cytosolic II Protéines (11) et 5'-Nucleotidase, Cytosolic II Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NT5C2 22978 P49902
NT5C2 76952 Q3V1L4
NT5C2 100363253  
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Top anti-5'-Nucleotidase, Cytosolic II Anticorps sur anticorps-enligne.fr

Showing 10 out of 62 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis in WiDr cell line lysates (35ug/lane) using NT5C2 Antibody . This demonstrates the NT5C2 antibody detected the NT5C2 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Souris Inconjugué IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to NT5C2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Western Blot analysis of NT5C2 expression in transfected 293T cell line by NT5C2 monoclonal antibody (M02), clone 3C1.Lane 1: NT5C2 transfected lysate(64.97 KDa).Lane 2: Non-transfected lysate. 100 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:H1299 B:HeLa S3, 7.5% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: mouse liver 7.5% SDS PAGE antibody diluted at 1:500 100 μL Connectez-vous pour afficher 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué WB NT5C2 Antibody (N-term) (ABIN656169) western blot analysis in WiDr cell line lysates (35 µg/lane). This demonstrates the NT5C2 antibody detected the NT5C2 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis NT5C2 using NIH-3T3 whole cell lysates ABIN6279343 at 1/100 staining Human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-NT5C2 Polyclonal Antibody, Unconjugated (ABIN739353) onjugated 100 μL Connectez-vous pour afficher 3 to 7 Days
$329.45
Détails
Humain Souris Inconjugué ELISA, IF, IHC, IHC (p), WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$537.17
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of GMPR using rabbit polyclonal GMPR Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GMPR gene. GMPR Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB   100 μL Connectez-vous pour afficher 11 to 14 Days
$537.17
Détails
Humain Lapin Inconjugué IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with NT5C2 polyclonal antibody  shows cytoplasmic positivity in seminiferous duct cells at 1:20-1:50 dilution. 100 μL Connectez-vous pour afficher 11 to 12 Days
$577.33
Détails

anti-5'-Nucleotidase, Cytosolic II Anticorps mieux référencés

  1. Human Monoclonal NT5C2 Primary Antibody pour IF, IHC (p) - ABIN524900 : Kulkarni, Karlsson, Szekeres, Chibalin, Krook, Zierath: Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. dans The Journal of biological chemistry 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal NT5C2 Primary Antibody pour IF (p), IHC (p) - ABIN739353 : Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells. dans Neuroscience 2012 (PubMed)

Plus d’anticorps contre 5'-Nucleotidase, Cytosolic II partenaires d’interaction

Human 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. Results uncover dynamic mechanisms of enzyme regulation targeted by chemotherapy resistance-driving NT5C2 mutations in relapsed acute lymphoblastic leukemia.

  2. intersubunit interaction forms structural basis of hyperactive NT5C2 in drug-resistant leukemia in which heterozygous NT5C2 mutation gave rise to hetero-tetramer mutant and WT proteins.

  3. NT5C2 mutations seem to have a broad clinical spectrum and should be sought in patients manifesting either as uncomplicated or complicated spastic paraplegia

  4. Using data from a large-scale genome-wide association study of schizophrenia, study identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR-206s binding to NT5C2 thus leading to increased expression of this gene.

  5. acute lymphoblastic leukemia-specific mutations affect regulation of cN-II

  6. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  7. NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.

  8. The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.

  9. Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.

  10. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  11. Data indicate that type II cytosolic 5'-nucleotidase (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.

  12. Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.

  13. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia

  14. results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia

  15. analysis of Drosophila and human 7-methyl GMP-specific nucleotidases

  16. Polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women.

  17. seven high-resolution structures of human cN-II, including a ligand-free form and complexes with various substrates and effectors, were presented.

  18. cN-II has a role in protecting against progression of non-small cell lung cancer

  19. the expression level of cN-II mRNA might be a prognostic factor of high-risk MDS.

  20. Data describe the crystal structure of human cytosolic 5'-nucleotidase II and discuss its allosteric regulation and substrate recognition.

Mouse (Murine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.

Cow (Bovine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain

5'-Nucleotidase, Cytosolic II (NT5C2) profil antigène

Profil protéine

This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.

Gene names and symbols associated with NT5C2

  • 5'-nucleotidase, cytosolic II (NT5C2) anticorps
  • 5'-nucleotidase, cytosolic II (nt5c2.L) anticorps
  • 5'-nucleotidase, cytosolic II (nt5c2) anticorps
  • 5'-nucleotidase, cytosolic IIa (nt5c2a) anticorps
  • 5'-nucleotidase, cytosolic II (Nt5c2) anticorps
  • 5'-nucleotidase, cytosolic II (surE2) anticorps
  • 2010002I23Rik anticorps
  • cN-II anticorps
  • CnII anticorps
  • ENSMUSG00000025039 anticorps
  • Gm9751 anticorps
  • Gmp anticorps
  • Nt5b anticorps
  • NT5C2 anticorps
  • Pnt5 anticorps
  • wu:fc36f11 anticorps
  • wu:fc45b10 anticorps

Protein level used designations for NT5C2

cytosolic 5'-nucleotidase II , cytosolic purine 5'-nucleotidase , 5'-nucleotidase, cytosolic II , fc36f11 , 5'-nucleotidase (purine), cytosolic type B , IMP-specific 5'-NT , purine 5' nucleotidase , 5'-nucleotidase cytosolic II , cytosolic IMP/GMP-specific 5'-nucleotidase , cytosolic purine 5'-nucleotidase-like

GENE ID SPECIES
477809 Canis lupus familiaris
444729 Xenopus laevis
548490 Xenopus (Silurana) tropicalis
714292 Macaca mulatta
324845 Danio rerio
22978 Homo sapiens
450706 Pan troglodytes
76952 Mus musculus
281951 Bos taurus
423871 Gallus gallus
100172749 Pongo abelii
5808749 Sorangium cellulosum So ce56
100363253 Rattus norvegicus
100402763 Callithrix jacchus
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