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NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.
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Human Monoclonal NT5C2 Primary Antibody pour IF, IHC (p) - ABIN524900
Kulkarni, Karlsson, Szekeres, Chibalin, Krook, Zierath: Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. dans The Journal of biological chemistry 2011
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Human Polyclonal NT5C2 Primary Antibody pour IF (p), IHC (p) - ABIN739353
Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells. dans Neuroscience 2012
NT5C2 mutations seem to have a broad clinical spectrum and should be sought in patients manifesting either as uncomplicated or complicated spastic paraplegia
Using data from a large-scale genome-wide association study of schizophrenia, study identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR (Montrer MLXIP Anticorps)-206s binding to NT5C2 thus leading to increased expression of this gene.
acute lymphoblastic leukemia-specific mutations affect regulation of cN-II
this study implicates altered neural expression of BORCS7, AS3MT (Montrer AS3MT Anticorps), and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.
The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.
Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.
cN-II co-immunoprecipitated both with wild type Ipaf (Montrer NLRC4 Anticorps) and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf (Montrer NLRC4 Anticorps) lacking the LRR domain.
Data indicate that type II cytosolic 5'-nucleotidase (Montrer NT5E Anticorps) (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.
Four novel body mass index-associated loci near the KCNQ1 (Montrer KCNQ1 Anticorps)(rs2237892), ALDH2 (Montrer ALDH2 Anticorps)/MYL2 (Montrer MYL2 Anticorps) (rs671, rs12229654), ITIH4 (Montrer ITIH4 Anticorps) (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.
The results on muscles from the NT5C (Montrer NT5C Anticorps) knockout mice contradict previous findings where AMP (Montrer TMPRSS5 Anticorps) levels and AMPK (Montrer PRKAA1 Anticorps) activity were shown to be modulated by NT5C (Montrer NT5C Anticorps) enzymes.
mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.
cytosolic 5'-nucleotidase II
, cytosolic purine 5'-nucleotidase
, 5'-nucleotidase, cytosolic II
, 5'-nucleotidase (purine), cytosolic type B
, IMP-specific 5'-NT
, purine 5' nucleotidase
, 5'-nucleotidase cytosolic II
, cytosolic IMP/GMP-specific 5'-nucleotidase
, cytosolic purine 5'-nucleotidase-like